A Retrospective Analysis of 2-Year Follow-Up of Patients with Incidental Findings of Sarcoidosis

被引:0
作者
Thomas-Orogan, Oluwabukola [1 ]
Barratt, Shaney L. [1 ]
Zafran, Muhammad [1 ]
Kwok, Apollo [2 ]
Simons, Anneliese [2 ]
Judge, Eoin P. [2 ]
Wells, Matthew [1 ]
Daly, Richard [3 ]
Sharp, Charles [1 ]
Jeyabalan, Abiramy [1 ]
Plummeridge, Martin [1 ]
Chandratreya, Ladli [4 ]
Spencer, Lisa G. [2 ]
Medford, Andrew R. L. [5 ]
Adamali, Huzaifa I. [1 ]
机构
[1] North Bristol NHS Trust, Bristol Interstitial Lung Dis Serv, Bristol BS10 5NB, England
[2] Liverpool Univ Hosp NHS Fdn Trust, Liverpool Interstitial Lung Dis Serv, Liverpool L7 8XP, England
[3] North Bristol NHS Trust, Dept Cellular Pathol, Bristol BS10 5NB, England
[4] North Bristol NHS Trust, Dept Radiol, Bristol BS10 5NB, England
[5] North Bristol NHS Trust, North Bristol Lung Ctr, Bristol BS10 5NB, England
关键词
sarcoidosis; thoracic lymphadenopathy; pulmonary sarcoidosis; follow-up; INTRATHORACIC SARCOIDOSIS; PULMONARY SARCOIDOSIS; LUNG-CANCER; PREVALENCE; CT; PROGNOSIS; MORTALITY; CHEST;
D O I
10.3390/diagnostics14030237
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Sarcoidosis is a multi-system granulomatous disease most commonly involving the lungs. It may be incidentally diagnosed during imaging studies for other conditions or non-specific symptoms. The appropriate follow-up of incidentally diagnosed asymptomatic stage 1 disease has not been well defined. Objective: To define the clinical course of incidentally diagnosed asymptomatic stage 1 sarcoidosis and propose an algorithm for the follow-up of these patients. Methodology: A retrospective case note analysis was performed of all EBUS-TBNA (endobronchial ultrasound-guided transbronchial needle aspiration)-confirmed cases of stage 1 sarcoidosis presenting incidentally to Bristol and Liverpool Interstitial Lung Disease services. Clinical history, serology results, imaging scans, and lung function parameters were examined at baseline, 12, and 24 months. A cost analysis was performed comparing the cost of the current 2-year follow-up guidance to a 1 year follow-up period. Results: Sixty-seven patients were identified as the final cohort. There was no significant change in the pulmonary function tests over the two-year follow-up period. Radiological disease stability was observed in the majority of patients (58%, n = 29), and disease regression was evidenced in 40% (n = 20) at 1 year. Where imaging was performed at 2 years, the majority (69.8%, n = 37) had radiological evidence of disease regression, and 30.2% (n = 16) showed radiological evidence of stability. All patients remained asymptomatic and did not require therapeutic intervention over the study period. Conclusions: Our results show that asymptomatic patients with incidental findings of thoracic lymph nodal non-caseating granulomas do not progress over a 2-year period. Our results suggest that the prolonged secondary-care follow-up of such patients may not be necessary. We propose that these patients are followed up for 1 year with a further year of patient-initiated follow-up (PIFU) prior to discharge.
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页数:11
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