Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy

被引:3
作者
Jose Bellini, Maria [1 ]
Labombarda, Florencia [2 ,3 ]
机构
[1] Univ Nacl La Plata, Lab Bioquim Envejecimiento, INIBIOLP CONICET, Fac Ciencias Med, La Plata, Argentina
[2] Univ Buenos Aires, Lab Neuroendocrine Biochem, IBYME CONICET, Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Med, Dept Human Biochem, Buenos Aires, DF, Argentina
关键词
cognitive impairments; gene therapy; hippocampus; insulin growth factor 1; microglial cells; neurodegeneration; neurogenesis; neuroinflammation; spinal cord injury; traumatic brain injury; ADULT HIPPOCAMPAL NEUROGENESIS; ENDOPLASMIC-RETICULUM STRESS; NEURAL STEM-CELLS; COGNITIVE IMPAIRMENT; INJURY; IGF-1; NEUROINFLAMMATION; ACTIVATION; MICROGLIA; APOPTOSIS;
D O I
10.4103/1673-5374.343902
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal cord injury, several reports have described impairments in cognitive abilities. Our group also has contributed significantly to the study of cognitive impairments in a rat model of spinal cord injury. These findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes, drugs of abuse, and combined medication. They are related to changes in brain structures involved in cognition and emotion, such as the hippocampus. Chronic spinal cord injury decreases neurogenesis, enhances glial reactivity leading to hippocampal neuroinflammation, and triggers cognitive deficits. These brain distal abnormalities are recently called tertiary damage. Given that there is no treatment for Tertiary Damage, insulin growth factor 1 gene therapy emerges as a good candidate. Insulin growth factor 1 gene therapy recovers neurogenesis and induces the polarization from pro-inflammatory towards anti-inflammatory microglial phenotypes, which represents a potential strategy to treat the neuroinflammation that supports tertiary damage. Insulin growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is crucial. Insulin growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.
引用
收藏
页码:253 / 257
页数:5
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