Durvalumab (D) plus /- tremelimumab (T) in combination with dose-dense MVAC (ddMVAC) as neoadjuvant treatment in patients with muscle-invasive bladder carcinoma (MIBC): Results of NEMIO, a randomized phase I-II trial

被引:7
作者
Thibault, C. [1 ]
Bennamoun, M. [2 ]
Flechon, A. [3 ]
Gravis, G. [4 ]
Pouessel, D. [5 ]
Combe, P-F. [6 ]
Borchiellini, D. [7 ]
Loriot, Y. [8 ]
Laguerre, B. [9 ]
Barthelemy, P. [10 ]
Goupil, M. Gross [11 ]
Helissey, C. [12 ]
Huillard, O. [13 ]
Cancel, M. [14 ]
Campedel, L. [15 ]
Audenet, F. [16 ]
Belhouari, H. [17 ]
Kotti, S. [17 ]
Tran, Y. [18 ]
Oudard, S. [1 ]
机构
[1] HEGP, AP HP, Med Oncol Dept, Paris, France
[2] Inst Mutualiste Montsouris, Oncol, Paris, France
[3] Ctr Leon Berard, Dept Med Oncol, Lyon, France
[4] IPC, Dept Med Oncol, Immun & Canc Team, Marseille, France
[5] Oncopole Claudius Regaud Inst Univ Canc, Dept Med Oncol, Toulouse, France
[6] Pole Sante Leonard de Vinci, Oncol, Chambray Les Tours, France
[7] Ctr Anticanc Antoine Lacassagne, Dept Med Oncol, Nice, France
[8] Inst Gustave Roussy, DITEP, Villejuif, France
[9] Ctr Eugene Marquis, Med Oncol, Rennes, France
[10] ICANS Inst Cancerol Strasbourg Europe, Dept Med Oncol, Strasbourg, France
[11] CHU Bordeaux Hop St Andre, Dept Med Oncol, Bordeaux, France
[12] Mil Hosp Begin, Clin Res Unit, St Mande, France
[13] Hop Cochin, AP HP, Cancerol, Paris, France
[14] Univ Hosp Tours, Dept Med Oncol, Tours, France
[15] Hop La Pitie Salpetriere, Dept Med Oncol, Paris, France
[16] HEGP, AP HP, Paris, France
[17] ARTIC, Med Oncol, Paris, France
[18] ARTIC, Stat, Paris, France
关键词
D O I
10.1016/j.annonc.2023.09.1013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2364MO
引用
收藏
页码:S1202 / S1202
页数:1
相关论文
共 38 条
[31]   CCTG CO.26 trial: A phase II randomized study of durvalumab (D) plus tremelimumab (T) and best supportive care (BSC) versus BSC alone in patients (pts) with advanced refractory colorectal carcinoma (rCRC). [J].
Chen, Eric Xueyu ;
Jonker, Derek J. ;
Kennecke, Hagen F. ;
Berry, Scott R. ;
Couture, Felix ;
Ahmad, Chaudhary E. ;
Goffin, John R. ;
Kavan, Petr ;
Harb, Mohammed ;
Colwell, Bruce ;
Samimi, Setareh ;
Samson, Benoit ;
Abbas, Tahir ;
Aucoin, Nathalie ;
Aubin, Francine ;
Koski, Sheryl L. ;
Wei, Alice Chia-chi ;
Magoski, Nadine M. ;
Tu, Dongsheng ;
O'Callaghan, Christopher J. .
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (04)
[32]   Randomized phase III trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) or gemcitabine and cisplatin (GC) as perioperative chemotherapy for muscle invasive urothelial bladder cancer (MIUBC): Preliminary results of the GETUG/AFU V05 VESPER trial on toxicity and pathological responses [J].
Culine, Stephane ;
Gravis, Gwenaelle ;
Flechon, Aude ;
Soulie, Michel ;
Guy, Laurent ;
Laguerre, Brigitte ;
Mottet, Nicolas ;
Joly, Florence ;
Allory, Yves ;
Harter, Valentin ;
Pfister, Christian .
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (06)
[33]   Preliminary efficacy and safety results from RC48-C017: A phase II study of neoadjuvant treatment with disitamab vedotin plus toripalimab in patients with muscle invasive bladder cancer (MIBC) with HER2 expression [J].
Sheng, Xinan ;
Yang, Kaiwei ;
Ji, Yongpeng ;
Zhou, Li ;
Zou, Benkui ;
Huang, Hang ;
Wang, Yonghua ;
Bai, Xue ;
Feng, Dan ;
Yang, Yong ;
Bian, Jiasheng ;
Yu, Zhixian ;
Niu, Haitao ;
Du, Peng ;
Fang, Jianmin ;
He, Zhisong ;
Guo, Jun .
JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
[34]   Phase II study of neoadjuvant dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) chemotherapy in patients with muscle-invasive urothelial cancer (MI-UC): Pathologic and radiologic response, serum tumor markers, and DNA excision repair pathway biomarkers in relation to disease-free survival (DFS) [J].
Qu, Angela Q. ;
Jacobus, Susanna J. ;
Signoretti, Sabina ;
Stack, Edward C. ;
Krajewski, Katherine Maragaret ;
Rosenberg, Jonathan E. ;
Choueiri, Toni K. .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
[35]   Randomized Phase III Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients with Muscle-invasive Bladder Cancer. Analysis of the GETUG/AFU V05 VESPER Trial Secondary Endpoints: Chemotherapy Toxicity and Pathological Responses [J].
Pfister, Christian ;
Gravis, Gwenaelle ;
Flechon, Aude ;
Soulie, Michel ;
Guy, Laurent ;
Laguerre, Brigitte ;
Mottet, Nicolas ;
Joly, Florence ;
Allory, Yves ;
Harter, Valentin ;
Culine, Stephane .
EUROPEAN UROLOGY, 2021, 79 (02) :214-221
[36]   Novel sequential treatment strategy for patients with muscle-invasive bladder cancer (MIBC): intravesical recombinant BCG, followed by neoadjuvant chemoimmunotherapy, radical cystectomy plus pelvic lymphadenectomy and adjuvant immunotherapy - protocol of a multicentre, single arm phase 2 trial (SAKK 06/19) [J].
Petrausch, Ulf ;
Spahn, Martin ;
Schneider, Martina ;
Hayoz, Stefanie ;
Rentsch, Cyrill A. ;
Rothschild, Sacha ;
Omlin, Aurelius ;
Cathomas, Richard .
BMJ OPEN, 2023, 13 (06)
[38]   SOGUG-NEOWIN: A phase II, open-label, multi-centre trial evaluating the efficacy and safety of erdafitinib (ERDA) monotherapy and ERDA and cetrelimab (CET) as neoadjuvant treatment in cisplatin-ineligible patients with muscle-invasive bladder cancer (MIBC) and FGFR gene alterations [J].
Loriot, Y. ;
Necchi, A. ;
Hussain, S. A. ;
De Velasco Oria, G. A. .
ANNALS OF ONCOLOGY, 2024, 35 :S1163-S1164