Durvalumab (D) plus /- tremelimumab (T) in combination with dose-dense MVAC (ddMVAC) as neoadjuvant treatment in patients with muscle-invasive bladder carcinoma (MIBC): Results of NEMIO, a randomized phase I-II trial

被引：4

作者：

Thibault, C. ^{[1
]}

Bennamoun, M. ^{[2
]}

Flechon, A. ^{[3
]}

Gravis, G. ^{[4
]}

Pouessel, D. ^{[5
]}

Combe, P-F. ^{[6
]}

Borchiellini, D. ^{[7
]}

Loriot, Y. ^{[8
]}

Laguerre, B. ^{[9
]}

Barthelemy, P. ^{[10
]}

Goupil, M. Gross ^{[11
]}

Helissey, C. ^{[12
]}

Huillard, O. ^{[13
]}

Cancel, M. ^{[14
]}

Campedel, L. ^{[15
]}

Audenet, F. ^{[16
]}

Belhouari, H. ^{[17
]}

Kotti, S. ^{[17
]}

Tran, Y. ^{[18
]}

Oudard, S. ^{[1
]}

机构：

[1] HEGP, AP HP, Med Oncol Dept, Paris, France

[2] Inst Mutualiste Montsouris, Oncol, Paris, France

[3] Ctr Leon Berard, Dept Med Oncol, Lyon, France

[4] IPC, Dept Med Oncol, Immun & Canc Team, Marseille, France

[5] Oncopole Claudius Regaud Inst Univ Canc, Dept Med Oncol, Toulouse, France

[6] Pole Sante Leonard de Vinci, Oncol, Chambray Les Tours, France

[7] Ctr Anticanc Antoine Lacassagne, Dept Med Oncol, Nice, France

[8] Inst Gustave Roussy, DITEP, Villejuif, France

[9] Ctr Eugene Marquis, Med Oncol, Rennes, France

[10] ICANS Inst Cancerol Strasbourg Europe, Dept Med Oncol, Strasbourg, France

[11] CHU Bordeaux Hop St Andre, Dept Med Oncol, Bordeaux, France

[12] Mil Hosp Begin, Clin Res Unit, St Mande, France

[13] Hop Cochin, AP HP, Cancerol, Paris, France

[14] Univ Hosp Tours, Dept Med Oncol, Tours, France

[15] Hop La Pitie Salpetriere, Dept Med Oncol, Paris, France

[16] HEGP, AP HP, Paris, France

[17] ARTIC, Med Oncol, Paris, France

[18] ARTIC, Stat, Paris, France

来源：

ANNALS OF ONCOLOGY | 2023年 / 34卷

关键词：

D O I：

10.1016/j.annonc.2023.09.1013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2364MO

引用

页码：S1202 / S1202

页数：1

共 38 条

[1] NEMIO: A randomized phase I-II trial evaluating efficacy and safety of dose dense MVAC (ddMVAC) plus durvalumab plus /- tremelimumab as neoadjuvant treatment in patients with bladder muscle-invasive urothelial carcinoma
Thibault, C.
Elaidi, R. T.
Pouessel, D.
Flechon, A.
Borchiellini, D.
Barthelemy, P.
Huillard, O.
Rouabah, M.
Braychenko, E.
Helali, I.
Audenet, F.
Oudard, S.
ANNALS OF ONCOLOGY, 2020, 31 : S723 - S723
[2] NEMIO: A randomized phase II trial evaluating efficacy and safety of dose dense MVAC (ddMVAC) plus durvalumab plus /- tremelimumab as neoadjuvant treatment in patients with bladder muscle-invasive urothelial carcinoma
Thibault, C.
Audenet, F.
Borchiellini, D.
Huillard, O.
Barthelemy, P.
Pouessel, D.
Flechon, A.
Blons, H.
Sautes-Fridman, C.
Sun, C-M.
Verkarre, V.
Pallet, N.
Mejean, A.
Rouabah, M.
Helali, I.
Elaidi, R-T.
Oudard, S.
ANNALS OF ONCOLOGY, 2019, 30
[3] Open-label phase II to evaluate the efficacy of NEoadjuvant dose-dense MVAC In cOmbination with durvalumab and tremelimumab in muscle-invasive urothelial carcinoma: NEMIO
Thibault, Constance
Elaidi, Reza
Vano, Yann-Alexandre
Rouabah, Mouna
Braychenko, Elena
Helali, Imen
Audenet, Francois
Oudard, Stephane
BULLETIN DU CANCER, 2020, 107 (05) : ES8 - ES15
[4] Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer
Iyer, Gopa
Balar, Arjun V.
Milowsky, Matthew I.
Bochner, Bernard H.
Dalbagni, Guido
Donat, S. Machele
Herr, Harry W.
Huang, William C.
Taneja, Samir S.
Woods, Michael
Ostrovnaya, Irina
Al-Ahmadie, Hikmat
Arcila, Maria E.
Riches, Jamie C.
Meier, Andreas
Bourque, Caitlin
Shady, Maha
Won, Helen
Rose, Tracy L.
Kim, William Y.
Kania, Brooke E.
Boyd, Mariel E.
Cipolla, Catharine K.
Regazzi, Ashley M.
Delbeau, Daniela
McCoy, Asia S.
Vargas, Hebert Alberto
Berger, Michael F.
Solit, David B.
Rosenberg, Jonathan E.
Bajorin, Dean F.
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (19) : 1949 - +
[5] Re: Multicenter Prospective Phase II Trial of Neoadjuvant Dose-dense Gemcitabine Plus Cisplatin in Patients with Muscle-invasive Bladder Cancer
Voskuilen, Charlotte S.
van der Heijden, Michiel S.
van Rhijn, Basw. G.
EUROPEAN UROLOGY, 2019, 76 (06) : 870 - 871
[6] Re: Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine plus Cisplatin in Patients with Muscle-Invasive Bladder Cancer
Chang, Sam S.
JOURNAL OF UROLOGY, 2020, 203 (04) : 659 - 660
[7] Neoadjuvant Dose-dense Gemcitabine and Cisplatin in Muscle-Invasive Bladder Cancer: Results of a Phase 2 Trial
Anari, Fern
O'Neill, John
Choi, Woonyoung
Chen, David Y. T.
Haseebuddin, Mohammed
Kutikov, Alexander
Dulaimi, Essel
Alpaugh, R. Katherine
Devarajan, Karthik
Greenberg, Richard E.
Bilusic, Marijo
Wong, Yu-Ning
Viterbo, Rosalia
Hoffman-Censitsc, Jean H.
Lallas, Costas D.
Trabulsic, Edouard J.
Smaldone, Marc
Geynisman, Daniel M.
Zibelman, Matthew
Lin, Jianqing
Kelly, W. Kevin
Uzzo, Robert
McConkey, David
Plimack, Elizabeth R.
EUROPEAN UROLOGY ONCOLOGY, 2018, 1 (01): : 54 - 60
[8] DUTRENEO Trial: A phase II randomized trial of DUrvalumab and TREmelimumab as NEOadjuvant approach in muscle-invasive urothelial bladder cancer (MIBC) patients prospectively selected by immune signature scores.
Grande, Enrique
Guerrero, Felix
Puente, Javier
Galante, Isabel
Duran, Ignacio
Fuentes, Javier
Alonso-Gordoa, Teresa
Burgos, Javier
Font Pous, Albert
Buisan, Oscar
Pinto, Alvaro
Alvarez-Maestro, Mario
Reig Torras, Oscar
Maroto, Pablo
Garcia del Muro, Xavier
Galvan, Patricia
Malats, Nuria
Prat, Aleix
Real, Francisco X.
Castellano, Daniel E.
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
[9] Phase II study of neoadjuvant chemotherapy with four cycles of dose-dense MVAC followed by radical cystectomy in Korean patients with muscle-invasive or locally advanced urothelial carcinoma of bladder
Park, Kwonoh
Lee, Hyun Jung
Kim, Tae Un
Ryu, Hwaseong
Ki, Yong Kan
Hong, Yun Jeong
Nam, Jong Kil
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2023, 19 (06) : 739 - 746
[10] Neoadjuvant dose-dense gemcitabine and cisplatin (DDGC) in patients (pts) with muscle-invasive bladder cancer (MIBC): Final results of a multicenter phase 11 study.
Plimack, Elizabeth R.
Hoffman-Censits, Jean H.
Kutikov, Alexander
Greenberg, Richard E.
Bilusic, Marijo
Chen, David Y. T.
Viterbo, Rosalia
Lallas, Costas D.
Lin, Jianqing
Trabulsi, Edouard John
Geynisman, Daniel M.
Kelly, William Kevin
Smaldone, Marc C.
Devarajan, Karthik
Adaire-Halenda, Beth
Cione, Charlotte
Kilpatrick, Deborah
Duncan, Gail
Wong, Yu-Ning
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)

← 1 2 3 4 →