Sigma-1 receptor and seizures

被引：14
作者：
Vavers, Edijs [1 ,2 ]
Zvejniece, Liga [1 ]
Dambrova, Maija [1 ,3 ]
机构：
[1] Latvian Inst Organ Synth, Lab Pharmaceut Pharmacol, Aizkraukles 21, LV-1006 Riga, Latvia
[2] Univ Tartu, Inst Chem, Fac Sci & Technol, Ravila 14a, EE-50411 Tartu, Estonia
[3] Riga Stradins Univ, Fac Pharm, Konsula 21, LV-1007 Riga, Latvia
来源：
PHARMACOLOGICAL RESEARCH | 2023年 / 191卷
基金：
欧盟地平线“2020”;
关键词：
Sigma-1; receptor; Seizures; Sigma-1 receptor knockout; Sigma-1 receptor ligands; Seizure -related comorbidities; Multidimensional drug target; METHYL-D-ASPARTATE; COCAINE-INDUCED CONVULSIONS; DEXTROMETHORPHAN BINDING-SITES; GUINEA-PIG BRAIN; PHENCYCLIDINE-LIKE DRUGS; MORPHINE-LIKE ANALGESICS; KAINATE-INDUCED SEIZURES; GATED CALCIUM-CHANNELS; ANTICONVULSANT PROPERTIES; ALLOSTERIC MODULATION;
D O I：
10.1016/j.phrs.2023.106771
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R ligands are underway testing therapies for the treatment of drug-resistant seizures, developmental and epileptic encephalopathies, and photosensitive ep-ilepsy. However, the direct molecular mechanism by which Sig1R modulates seizures and the balance between excitatory and inhibitory pathways has not been fully elucidated. This review article aims to summarize existing knowledge of Sig1R and its involvement in seizures by focusing on the evidence obtained from Sig1R knockout animals and the anti-seizure effects of Sig1R ligands. In addition, this review article includes a discussion of the advantages and disadvantages of the use of existing compounds and describes the challenges and future per-spectives on the use of Sig1R as a target for the treatment of seizure disorders.
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页数：27
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