N6-methyladenosine (m6A) Modification in Preeclampsia

被引：8

作者：

Zhang, Tingting ^{[1
]}

Jiang, Ziyan ^{[1
]}

Yang, Nana ^{[1
]}

Ge, Zhiping ^{[1
]}

Zuo, Qing ^{[1
]}

Huang, Shiyun ^{[1
]}

Sun, Lizhou ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

来源：

REPRODUCTIVE SCIENCES | 2023年 / 30卷 / 11期

关键词：

Preeclampsia; N6-methyladenosine; Placenta; Trophoblast; RNA METHYLATION; NUCLEAR-RNA; TRANSLATION; DEMETHYLASE; DATABASE; ALKBH5;

D O I：

10.1007/s43032-023-01250-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification. In addition, epitranscriptional modification of m6A is closely related to the metabolic processes of placental tissues and cells in preeclampsia. This article reviews the composition, mode of action, and bioinformatics analysis of m6A modification-related proteins, and their biological function in the progression of preeclampsia. The relationship between m6A modification and preeclampsia risk factors, such as diabetes, cardiovascular disease, obesity, and psychological stress, is summarized to provide new ideas for studying PE-targeting molecules.

引用

页码：3144 / 3152

页数：9

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