Deuteration of heptamethine cyanine dyes enhances their emission efficacy

被引：12

作者：

Janekova, Hana ^{[1
]}

Friedman, Hannah C. ^{[2
]}

Russo, Marina ^{[1
]}

Zyberaj, Mergime ^{[1
]}

Ahmed, Tasnim ^{[2
]}

Hua, Ash Sueh ^{[2
]}

Sica, Anthony V. ^{[2
]}

Caram, Justin R. ^{[2
]}

Stacko, Peter ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, Wintherthurerstr 190, CH-8057 Zurich, Switzerland

[2] Univ Calif Los Angeles, Dept Chem & Biochem, 607 Charles E Young Dr, Los Angeles, CA 90095 USA

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 08期

基金：

瑞士国家科学基金会; 美国国家科学基金会;

关键词：

Deuterium - Infrared radiation - Quantum theory;

D O I：

10.1039/d3cc05153f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design of bright short-wave infrared fluorophores remains a grand challenge. Here we investigate the impact of deuteration on the properties in a series of heptamethine dyes, the absorption of which spans near-infrared and SWIR regions. We demonstrate that it is a generally applicable strategy that leads to enhanced quantum yields of fluorescence, longer-lived singlet excited states and suppressed rates of non-radiative deactivation processes. .

引用

页码：1000 / 1003

页数：4

共 31 条

[1] Computational Design, Synthesis, and Photochemistry of Cy7-PPG, an Efficient NIR-Activated Photolabile Protecting Group for Therapeutic Applications [J].

Alachouzos, Georgios ;

Schulte, Albert M. ;

Mondal, Anirban ;

Szymanski, Wiktor ;

Feringa, Ben L. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (27)

[2] Molecular design of near infrared polymethine dyes: A review [J].

Bricks, Julia L. ;

Kachkovskii, Alexei D. ;

Slominskii, Yurii L. ;

Gerasov, Andrii O. ;

Popov, Sergei V. .

DYES AND PIGMENTS, 2015, 121 :238-255

[3] Next-generation in vivo optical imaging with short-wave infrared quantum dots [J].

Bruns, Oliver T. ;

Bischof, Thomas S. ;

Harris, Daniel K. ;

Franke, Daniel ;

Shi, Yanxiang ;

Riedemann, Lars ;

Bartelt, Alexander ;

Jaworski, Frank B. ;

Carr, Jessica A. ;

Rowlands, Christopher J. ;

Wilson, Mark W. B. ;

Chen, Ou ;

Wei, He ;

Hwang, Gyu Weon ;

Montana, Daniel M. ;

Coropceanu, Igor ;

Achorn, Odin B. ;

Kloepper, Jonas ;

Heeren, Joerg ;

So, Peter T. C. ;

Fukumura, Dai ;

Jensen, Klavs F. ;

Jain, Rakesh K. ;

Bawendi, Moungi G. .

NATURE BIOMEDICAL ENGINEERING, 2017, 1 (04)

[4] Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color In Vivo Imaging with Shortwave Infrared Detection [J].

Cosco, Emily D. ;

Arus, Bernardo A. ;

Spearman, Anthony L. ;

Atallah, Timothy L. ;

Lim, Irene ;

Leland, Olivia S. ;

Caram, Justin R. ;

Bischof, Thomas S. ;

Bruns, Oliver T. ;

Sletten, Ellen M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 143 (18) :6836-6846

[5] Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time [J].

Cosco, Emily D. ;

Spearman, Anthony L. ;

Ramakrishnan, Shyam ;

Lingg, Jakob G. P. ;

Saccomano, Mara ;

Pengshung, Monica ;

Arus, Bernardo A. ;

Wong, Kelly C. Y. ;

Glasl, Sarah ;

Ntziachristos, Vasilis ;

Warmer, Martin ;

McLaughlin, Ryan R. ;

Bruns, Oliver T. ;

Sletten, Ellen M. .

NATURE CHEMISTRY, 2020, 12 (12) :1123-+

[6] Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging [J].

Cosco, Emily D. ;

Caram, Justin R. ;

Bruns, Oliver T. ;

Franke, Daniel ;

Day, Rachael A. ;

Farr, Erik P. ;

Bawendi, Moungi G. ;

Sletten, Ellen M. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (42) :13126-13129

[7] Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging [J].

Ding, Feng ;

Zhan, Yibei ;

Lu, Xiaoju ;

Sun, Yao .

CHEMICAL SCIENCE, 2018, 9 (19) :4370-4380

[8] Establishing design principles for emissive organic SWIR chromophores from energy gap laws [J].

Friedman, Hannah C. ;

Cosco, Emily D. ;

Atallah, Timothy L. ;

Jia, Shang ;

Sletten, Ellen M. ;

Caram, Justin R. .

CHEM, 2021, 7 (12) :3359-3376

[9]

Henry B. R., 1973, ORGANIC MOL PHOTOPHY

[10] Relationship between room temperature phosphorescence and deuteration position in a purely aromatic compound [J].

Hirata, S. ;

Totani, K. ;

Watanabe, T. ;

Kaji, H. ;

Vacha, M. .

CHEMICAL PHYSICS LETTERS, 2014, 591 :119-125

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