Amyloid-beta and tau protein beyond Alzheimer's disease

被引：48

作者：

Abyadeh, Morteza ^{[1
]}

Gupta, Vivek ^{[2
]}

Paulo, Joao A. ^{[3
]}

Mahmoudabad, Arezoo Gohari

Shadfar, Sina ^{[2
]}

Mirshahvaladi, Shahab ^{[2
]}

Gupta, Veer ^{[4
]}

Nguyen, Christine T. O. ^{[5
]}

Finkelstein, David I. ^{[6
]}

You, Yuyi

Haynes, Paul A. ^{[7
]}

Salekdeh, Ghasem H. ^{[7
]}

Graham, Stuart L. ^{[2
]}

Mirzaei, Mehdi ^{[2
]}

机构：

[1] ProGene Technol Pty Ltd, Sydney, NSW, Australia

[2] Macquarie Univ, Macquarie Med Sch, Dept Clin Med, Fac Med Hlth & Human Sci, Sydney, NSW, Australia

[3] Harvard Med Sch, Dept Cell Biol, Boston, MA USA

[4] Deakin Univ, Sch Med, Geelong, Vic, Australia

[5] Univ Melbourne, Sch Hlth Sci, Fac Med Dent & Hlth Sci, Dept Optometry & Vis Sci, Parkville, Vic, Australia

[6] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[7] Macquarie Univ, Sch Nat Sci, Macquarie Pk, NSW, Australia

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 06期

关键词：

amyloid-beta; cancer; cardiovascular diseases; diabetes; neurodegeneration; Tau; traumatic brain injury; CHRONIC TRAUMATIC ENCEPHALOPATHY; PRECURSOR-LIKE PROTEIN-2; FRONTOTEMPORAL LOBAR DEGENERATION; AUTISM SPECTRUM DISORDER; TYPE-2; DIABETES-MELLITUS; LONG-TERM ACCUMULATION; ALPHA-SYNUCLEIN; A-BETA; CEREBROSPINAL-FLUID; DOWN-SYNDROME;

D O I：

10.4103/1673-5374.386406

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, post-translational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

引用

页码：1262 / 1276

页数：15

共 383 条

[1] Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue [J].