Heart Failure-Related Iron Deficiency Anemia Pathophysiology and Laboratory Diagnosis

被引：3

作者：

Augusto, Silvio Nunes ^{[1
]}

Martens, Pieter ^{[2
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Cardiovasc & Metab Sci, Cleveland, OH USA

[2] Cleveland Clin, Heart Vasc & Thorac Inst, Kauffman Ctr Heart Failure Treatment & Recovery, Dept Cardiovasc Med, 9500 Euclid Ave, Cleveland, OH 44195 USA

来源：

CURRENT HEART FAILURE REPORTS | 2023年 / 20卷 / 05期

关键词：

Iron deficiency; Heart failure; Pathophysiology; FAILING HEART; CARDIOMYOCYTES; PREVALENCE; METABOLISM; MECHANISMS; SURVIVAL; DISEASE; SERUM;

D O I：

10.1007/s11897-023-00623-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review The goal of the current review is to give an overview regarding the pathophysiology of iron deficiency in heart failure and how different laboratory tests change in the setting of heart failure.Recent Findings Recent studies have questioned the current employed definition of iron deficiency in the field of heart failure, as patients with ferritin < 100ng/ml but TSAT > 20% have a better prognosis, no iron deficiency on bone marrow staining, and altered treatment response to ferric carboxymaltose.Summary This review summarizes changes in iron parameters in the setting of heart failure and underscores the importance of a reduced bioavailability of iron documented by a low serum iron or TSAT, irrespective of the presence of anemia.

引用

页码：374 / 381

页数：8

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