Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

被引:27
作者
Masse, Karly E. [1 ]
Lu, Van B. [1 ]
机构
[1] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金
加拿大自然科学与工程研究理事会;
关键词
enteroendocrine cells (EEC); gut microbiota; short-chain fatty acids (SCFAs); bile acids (BAs); indoles; glucagon-like peptide-1; signal transduction; GLUCAGON-LIKE PEPTIDE-1; TYPE-2; DIABETES-MELLITUS; FIBROBLAST-GROWTH-FACTOR; BETA-MURICHOLIC ACID; FARNESOID X RECEPTOR; DIET-INDUCED OBESITY; Y GASTRIC BYPASS; INSULIN SENSITIVITY; NUCLEAR RECEPTOR; FOOD-INTAKE;
D O I
10.3389/fendo.2023.1169624
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that can influence chemosensory cells lining the gastrointestinal tract. Specifically, hormone-releasing enteroendocrine cells which express a host of receptors activated by these bacterial metabolites. This review will focus on the activation mechanisms of glucagon-like peptide-1 releasing enteroendocrine cells by the three main bacterial metabolites produced in the gut: short-chain fatty acids, secondary bile acids and indoles. Given the importance of enteroendocrine cells in regulating glucose homeostasis and food intake, we will also discuss therapies based on these bacterial metabolites used in the treatment of metabolic diseases such as diabetes and obesity. Elucidating the mechanisms gut bacteria can influence cellular function in the host will advance our understanding of this fundamental symbiotic relationship and unlock the potential of harnessing these pathways to improve human health.
引用
收藏
页数:19
相关论文
共 269 条
  • [1] The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
    Abildgaard, Anders
    Elfving, Betina
    Hokland, Marianne
    Wegener, Gregers
    Lund, Sten
    [J]. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2018, 124 (04) : 306 - 312
  • [2] Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
    Adrian, T. E.
    Gariballa, S.
    Parekh, K. A.
    Thomas, S. A.
    Saadi, H.
    Al Kaabi, J.
    Nagelkerke, N.
    Gedulin, B.
    Young, A. A.
    [J]. DIABETOLOGIA, 2012, 55 (09) : 2343 - 2347
  • [3] Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
    Agus, Allison
    Planchais, Julien
    Sokol, Harry
    [J]. CELL HOST & MICROBE, 2018, 23 (06) : 716 - 724
  • [4] The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic -cell in rodent
    Al-Amily, Israa Mohammad
    Duner, Pontus
    Groop, Leif
    Salehi, Albert
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2019, 471 (04): : 633 - 645
  • [5] Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids
    Albaugh, Vance L.
    Flynn, Charles Robb
    Cai, Steven
    Xiao, Yi
    Tamboli, Robyn A.
    Abumrad, Naji N.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (09) : E1225 - E1233
  • [6] Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS
    Alnouti, Yazen
    Csanaky, Ivan L.
    Klaassen, Curtis D.
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 873 (02): : 209 - 217
  • [7] Fermentable Carbohydrate Alters Hypothalamic Neuronal Activity and Protects Against the Obesogenic Environment
    Anastasovska, Jelena
    Arora, Tulika
    Canon, Gina J. Sanchez
    Parkinson, James R. C.
    Touhy, Kieran
    Gibson, Glen R.
    Nadkarni, Nachiket A.
    So, Po-Wah
    Goldstone, Anthony P.
    Thomas, E. Louise
    Hankir, Mohammed K.
    Van Loo, Jan
    Modi, Neena
    Bell, Jimmy D.
    Frost, Gary
    [J]. OBESITY, 2012, 20 (05) : 1016 - 1023
  • [8] FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
    Ang, Zhiwei
    Xiong, Ding
    Wu, Min
    Ding, Jeak Ling
    [J]. FASEB JOURNAL, 2018, 32 (01) : 289 - +
  • [10] Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways
    Aoyama, Michiko
    Kotani, Joji
    Usami, Makoto
    [J]. NUTRITION, 2010, 26 (06) : 653 - 661