Novel Molecular Mechanisms Involved in the Medical Treatment of Pulmonary Arterial Hypertension

被引：8

作者：

Martin de Miguel, Irene ^{[1
,2
]}

Cruz-Utrilla, Alejandro ^{[1
,2
,3
]}

Oliver, Eduardo ^{[3
,4
]}

Escribano-Subias, Pilar ^{[1
,2
,3
]}

机构：

[1] Hosp Univ 12 Octubre, Cardiol Dept, Pulm Hypertens Multidisciplinary Unit, Madrid 28041, Spain

[2] Inst Invest Sanitaria Hosp 12 Octubre i, Madrid 28041, Spain

[3] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain

[4] Ctr Invest Biol Margarita Salas CIB CSIC, Madrid 28040, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

pulmonary arterial hypertension; vascular remodeling; endothelial dysfunction; BMP signaling; tyrosine kinase receptor; inflammation; epigenetics; mitochondrial dysfunction; VENTRICULAR DIASTOLIC DYSFUNCTION; SMOOTH-MUSCLE-CELLS; ADVENTITIAL FIBROBLASTS; ENDOTHELIAL DYSFUNCTION; DOUBLE-BLIND; K+ CHANNELS; PPAR-GAMMA; ACTIVIN-A; THERAPY; BMPR2;

D O I：

10.3390/ijms24044147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pulmonary arterial hypertension (PAH) is a severe condition with a high mortality rate despite advances in diagnostic and therapeutic strategies. In recent years, significant scientific progress has been made in the understanding of the underlying pathobiological mechanisms. Since current available treatments mainly target pulmonary vasodilation, but lack an effect on the pathological changes that develop in the pulmonary vasculature, there is need to develop novel therapeutic compounds aimed at antagonizing the pulmonary vascular remodeling. This review presents the main molecular mechanisms involved in the pathobiology of PAH, discusses the new molecular compounds currently being developed for the medical treatment of PAH and assesses their potential future role in the therapeutic algorithms of PAH.

引用

页数：20

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