Synthesis of the Macrolactone Cores of Maltepolides via a Diene-Ene Ring-Closing Metathesis Strategy

被引：5

作者：

Sit, Man Ki ^{[1
,2
]}

Cao, Hui Hui ^{[3
]}

Wu, Yan-Dong ^{[1
,2
,4
]}

Yip, Tsz Chun ^{[1
,2
]}

Bendel, Lars Eric ^{[1
,2
]}

Zhang, Wen ^{[1
,2
]}

Dai, Wei-Min ^{[1
,2
]}

机构：

[1] Hong Kong Univ Sci & Technol, Hong Kong Branch, Southern Marine Sci & Engn Guangdong Lab Guangzhou, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Lab Adv Catalysis & Synth, Kowloon, Hong Kong, Peoples R China

[3] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China

[4] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 10期

关键词：

CROSS-COUPLING REACTION; ALDOL REACTION; SUZUKI; GENERATION; REDUCTION; CATALYSTS; APHOS;

D O I：

10.1021/acs.orglett.3c00106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the C19-truncated maltepolide E has been accomplished via a diene-ene ring-closing metathesis (RCM) strategy without damage to the C11-C14 alkenyl epoxy unit. Upon release of the C17-OH group, it attacked at the C14 position with double bond migration and epoxide ring opening to furnish the C19-truncated maltepolides A and B as proposed for the biosynthesis of maltepolides.

引用

页码：1633 / 1637

页数：5

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