Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines

被引：12

作者：

Martins, Fabiane Ferreira ^{[1
]}

Souza-Mello, Vanessa ^{[1
]}

Aguila, Marcia Barbosa ^{[1
]}

Mandarim-de-Lacerda, Carlos Alberto ^{[1
]}

机构：

[1] Univ Estado Rio de Janeiro, Ctr Biomed, Inst Biol, Lab Morfometria Metab & Doenca Cardiovasc, Av 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil

来源：

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2023年 / 44卷 / 02期

关键词：

batokines; bone morphogenetic protein 8; fibroblast growth factor-21; neuregulin; 4; vascular endothelial growth factor A; ENDOTHELIAL GROWTH-FACTOR; GENE-EXPRESSION; THERMOGENESIS; ADIPOGENESIS; INFLAMMATION; HOMEOSTASIS; MYOSTATIN; OREXIN; BMP8B; MICE;

D O I：

10.1515/hmbci-2022-0044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.

引用

页码：219 / 227

页数：9

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