The predictive value of sarcopenia and myosteatosis in trans-arterial (chemo)-embolization treated HCC patients

被引:5
作者
Long, Jing [1 ]
Zhang, Xin [1 ]
Mi, Wei [1 ]
Shi, Jianjun [1 ]
Ren, Hongwei [2 ]
Wang, Qiang [1 ]
机构
[1] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Intervent Radiol, Wuhan, Hubei, Peoples R China
[2] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Imaging, Wuhan, Hubei, Peoples R China
来源
AGING-US | 2024年 / 16卷 / 01期
关键词
sarcopenia; skeletal muscle index; psoas muscle index; myosteasis; prognosis; trans-arterial (chemo)-embolization; hepatocellular carcinoma; INJECTION-DRUG USERS; SUBSTANCE USE DISORDERS; STRUCTURAL STIGMA; HARM REDUCTION; ERVING GOFFMAN; SELF-STIGMA; POLICE; OVERDOSE; ADDICTION; PEOPLE;
D O I
10.18632/aging.205375
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background: We conducted a meta-analysis to provide evidence-based results for the predictive values of sarcopenia, skeletal muscle index, psoas muscle index and the myosteatosis regarding the impact of survival outcomes and tumor response in patients treated by trans-arterial (chemo)-embolization (TAE/TACE), thereby optimizing therapeutic strategies and maximizing clinical benefits for hepatocellular carcinoma patients. Methods: Qualified studies were retrieved from PubMed, the Cochrane Library, EMBASE, and Google Scholar before June 19, 2023. We investigated the relationships between sarcopenia, SMI, PMI, myosteatosis, and the overall survival of TAE/TACE-treated hepatocellular carcinoma patients with pooling data. Results: A total of 167 studies were collected and 12 studies were finally included for analysis. The metaanalysis assisted that the sarcopenia (HR: 1.46, 95% CI: 1.30-1.64, p < 0.001), skeletal muscle index (HR: 1.48, 95% CI: 1.29-1.69, p < 0.001), and psoas muscle index (HR: 1.45, 95% CI: 1.19-1.77, p < 0.001) were significantly related to a shorter OS of hepatocellular carcinoma patients who treated by TAE/TACE. Sarcopenia significantly contributed to a lower objective response rate of TAE/TACE treated hepatocellular carcinoma patients (OR: 0.80, 95% CI: 0.65-0.98, p = 0.032). But there was no significant association between the myosteatosis and the overall survival (HR: 1.29, 95% CI: 0.74-2.25, p = 0.366). Sensitivity analysis supported the stability and dependability of above analyses conclusions. Conclusion: Sarcopenia, skeletal muscle index and psoas muscle index, are significant prognostic predictors for TAE/TACE treated hepatocellular carcinoma patients. While myosteasis does not demonstrate a prognostic impact on the overall survival of TAE/TACE treated hepatocellular carcinoma patients.
引用
收藏
页码:389 / 401
页数:13
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