Generation of a human iPSC line (CHCMUi002-A) from peripheral blood mononuclear cells from a chronic granulomatous disease patient

被引：0

作者：

Zeng, Anle ^{[1
,2
]}

Ni, Ke ^{[3
]}

Fang, Shuyu ^{[1
,2
]}

Yu, Lang ^{[1
,2
]}

Gao, Yelei ^{[1
,2
]}

Zhou, Lina ^{[1
,2
]}

Zhao, Xiaodong ^{[1
,2
]}

机构：

[1] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Infect & Immun, Minist Educ Key Lab Child Dev & Disorders, Chongqing, Peoples R China

[2] Childrens Hosp Chongqing Med Univ, Div Rheumatol & Immunol, Chongqing, Peoples R China

[3] Aldit Therapeut, Hangzhou, Zhejiang, Peoples R China

来源：

STEM CELL RESEARCH | 2024年 / 74卷

关键词：

D O I：

10.1016/j.scr.2023.103269

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Chronic granulomatous disease (CGD) is a rare X-linked recessive primary immunodeficiency disease (PID). Herein, a human induced pluripotent stem cell (iPSC) line was generated from the peripheral blood mononuclear cells (PBMCs) of a CGD patient with a mutation (c.785_786delTT) in the CYBB gene. These iPSCs showed the expression of pluripotency markers, the ability to differentiate into three germ layers. They offer a promising technique for studying the pathogenesis and conducting drug screening for CGD patients.

引用

页数：3