Development and Immunoprotection of Bacterium-like Particle Vaccine against Infectious Bronchitis in Chickens

被引：1
作者：
Zhang, Pengju [1 ]
Yang, Tiantian [2 ]
Sun, Yixue [3 ]
Qiao, Haiying [1 ]
Hu, Nianzhi [1 ]
Li, Xintao [1 ]
Wang, Weixia [1 ]
Zhang, Lichun [1 ]
Cong, Yanlong [2 ]
机构：
[1] Jilin Acad Agr Sci, Inst Anim Biotechnol, Changchun 130033, Peoples R China
[2] Jilin Univ, Coll Vet Med, Lab Infect Dis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China
[3] Changchun Univ, Dept Pol & Regulat, Changchun 130022, Peoples R China
来源：
VACCINES | 2023年 / 11卷 / 08期
关键词：
infectious bronchitis virus; S1; subunit; bacterium-like particles; immunoprotective; MOLECULAR CHARACTERIZATION; SOUTHWESTERN CHINA; VIRUS; GENOTYPE; RECOMBINATION; PATHOGENICITY; CORONAVIRUS; RESPONSES; S1; IDENTIFICATION;
D O I：
10.3390/vaccines11081292
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Infectious bronchitis (IB) is a major threat to the global poultry industry. Despite the availability of commercial vaccines, the IB epidemic has not been effectively controlled. The exploration of novel IBV vaccines may provide a new way to prevent and control IB. In this study, BLP-S1, a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus (IBV), was constructed using the GEM-PA surface display system. The immunoprotective efficacy results showed that BLP-S1 can effectively induce specific IgG and sIgA immune responses, providing a protection rate of 90% against IBV infection in 14-day-old commercial chickens. These results suggest that BLP-S1 has potential for the development of novel vaccines with good immunogenicity and immunoprotection.
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页数：12
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