The Frailty Index and colon cancer: a 2-sample Mendelian- randomization study

被引:7
作者
Gao, Lingling [1 ]
Di, Xiaoling [2 ]
Gao, Lulu [3 ]
Liu, Zhanhui [4 ]
Hu, Fengping [5 ]
机构
[1] Hebei Med Univ, Hosp 1, Dept Med Lab, Shijiazhuang, Peoples R China
[2] Peoples Hosp Dingzhou, Dept Gland Surg, Dingzhou, Peoples R China
[3] Hebei Med Univ, Hosp 1, Hlth Serv Ctr, Shijiazhuang, Peoples R China
[4] Hebei Med Univ, Hosp 1, Dept Radiol & Nucl Med, 89 Donggang Rd, Shijiazhuang 050031, Peoples R China
[5] Hebei Univ Tradit Chinese Med, Hebei Hosp Tradit Chinese Med, Affiliated Hosp 1, Dept Med Lab, 389 Zhongshan East Rd, Shijiazhuang 050011, Peoples R China
关键词
Frailty; cancer; risk; 2-sample Mendelian-randomization study; DIABETES-MELLITUS INCREASES; CHRONIC KIDNEY-DISEASE; PREVALENCE; RISK; ASSOCIATION;
D O I
10.21037/jgo-23-134
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Frailty is closely related to cancer. Previous research has shown that cancer patients are prone to frailty, and frailty increases the risk of adverse outcomes in cancer patients. However, it is unclear whether frailty increases the risk of cancer. This 2-sample Mendelian-randomization (MR) study sought to analyze the relationship between frailty and the risk of colon cancer. Methods: The database was extracted from the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) in 2021. The genome-wide association study (GWAS) data related to colon cancer was obtained from the GWAS website (http://gwas.mrcieu.ac.uk/datasets), involving 462,933 individuals' gene information. Single-nucleotide polymorphisms (SNPs) were defined as the instrumental variables (IVs). The SNPs closely associated with the Frailty Index at a genome-wide significance level were selected. To further screen the IVs, we selected the confounding factors using the PhenoScanner (http://www.phenoscanner. medschl.cam.ac.uk/phenoscanner). To estimate the causal effect of the Frailty Index on colon cancer, the MR-Egger regression, weighted median (WM1), inverse-variance weighted (IVW), and weight mode (WM2) methods were applied to calculate the SNP-frailty index and the SNP-cancer estimates. Cochran's Q statistic was used to estimate heterogeneity. The two-sample Mendelian randomization (TSMR) analysis was performed using the "TwoSampleMR" and "plyr" packages. All the statistical tests were 2-tailed, and a P value <0.05 was considered statistically significant. Results: We selected 8 SNPs as the IVs. The results of the IVW analysis [odds ratio (OR) =0.995, 95% confidence interval (CI): 0.990-1.001, P=0.052] showed that the genetic changes in the Frailty Index were not statistically associated with the risk of colon cancer, and no significant heterogeneity between these 8 genes was observed (Q =7.382, P=0.184). The MR-Egger (OR =0.987, 95% CI: 0.945-1.031, P=0.581), WM1 (OR =0.995, 95% CI: 0.990-1.001, P=0.118), WM2 (OR =0.996, 95% CI: 0.988-1.004, P=0.356), and SM (OR =0.996, 95% CI: 0.987-1.005, P=0.449) results were also consistent with each other. The sensitivity analysis based on the leave-one-out method showed that the individual SNPs did not affect the robustness of the results. Conclusions: Frailty might have no effect on the risk of colon cancer.
引用
收藏
页码:798 / 805
页数:8
相关论文
共 50 条
[41]   The causal relationship between hallux valgus and endogenous pathogenic factors: A 2-sample Mendelian randomization [J].
Xie, Yuan Lei ;
Liang, Jia Yuan ;
Du, Gen Fa ;
Lu, Hui Jun ;
Luo, Wei Jie ;
Wu, Jia Heng ;
Sheng, Zhao Hui .
MEDICINE, 2025, 104 (08) :e41647
[42]   Relationship Between Chronic Pain and Breast Cancer: Insight From Genetic Correlation Analyses and 2-Sample Mendelian Randomization [J].
Yang, Haojie ;
Xie, Xiaoyan ;
Lin, Liling ;
Tan, Zicong ;
Liu, Zhongqi ;
Zhang, Yangfan ;
Ji, Fengtao ;
Che, Yuejuan .
CLINICAL BREAST CANCER, 2025, 25 (05) :e533-e544
[43]   Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis [J].
Sun, Weichu ;
Xiao, Hui ;
Li, Yayun .
AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2024, 36 (01)
[44]   Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study [J].
Wu, Dongsheng ;
Zhou, Jian ;
Huang, Yuchen ;
Zheng, Quan ;
Wang, Tengyong ;
Liu, Lunxu .
CANCER MEDICINE, 2023, 12 (17) :18418-18424
[45]   The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A 2-Sample Mendelian Randomization Study [J].
Leppert, Beate ;
Riglin, Lucy ;
Wootton, Robyn E. ;
Dardani, Christina ;
Thapar, Ajay ;
Staley, James R. ;
Tilling, Kate ;
Smith, George Davey ;
Thapar, Anita ;
Stergiakouli, Evie .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2021, 190 (06) :1047-1055
[46]   The risk of common hypoglycemic and antihypertensive medications and COVID-19: A 2-sample Mendelian randomization study [J].
Wang, Ya ;
Li, Kai ;
Zeng, Jiaxing ;
Lu, Shunyu ;
Deng, Wangsheng .
MEDICINE, 2024, 103 (06) :E36423
[47]   Crohn disease but not ulcerative colitis increases the risk of acute pancreatitis: A 2-sample Mendelian randomization study [J].
Fu, Xuewei ;
Wu, Hao ;
Shu, Yufeng ;
Yang, Bocheng ;
Deng, Chao .
MEDICINE, 2024, 103 (23) :e38317
[48]   Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study [J].
Fang, Yifan ;
Liu, Lan ;
Yang, Yingying ;
Zhang, Bing ;
Xie, Siqi .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2024, 110 (01) :41-47
[49]   Relationship of α-Klotho with Frailty Index and Sarcopenia: A Bidirectional Mendelian Randomization Study [J].
Zhu, Yue ;
Hong, Guo-Jun ;
Hu, Yong ;
Wu, Rui .
REJUVENATION RESEARCH, 2025, 28 (03) :146-155
[50]   Types of milk consumed and risk of essential hypertension: A 2-sample Mendelian randomization analysis [J].
Shi, Zhangyan ;
Zhao, Ze ;
Zhu, Puyan ;
An, Caiyan ;
Zhang, Kejin .
JOURNAL OF DAIRY SCIENCE, 2023, 106 (07) :4516-4523