Age and sex differentially shape brain networks in Parkinson's disease

被引：18
作者：
Chen, Zhichun [1 ,2 ,3 ]
Wu, Bin [4 ]
Li, Guanglu [1 ,2 ]
Zhou, Liche [1 ,2 ]
Zhang, Lina [5 ]
Liu, Jun [1 ,2 ,6 ,7 ]
机构：
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Neurol, Changsha, Peoples R China
[4] Henan Univ Sci & Technol, Xuchang Cent Hosp, Dept Neurol, Luoyang, Henan, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Med, Dept Biostat, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai 200025, Peoples R China
[7] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai 200025, Peoples R China
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2023年 / 29卷 / 07期
基金：
中国国家自然科学基金;
关键词：
age; clinical phenotype; network; Parkinson's disease; sex; GENDER-DIFFERENCES; CORTICAL THICKNESS; ORGANIZATION; DRUG;
D O I：
10.1111/cns.14149
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Aims: Age and sex are important individual factors modifying the clinical symptoms of patients with Parkinson's disease (PD). Our goal is to evaluate the effects of age and sex on brain networks and clinical manifestations of PD patients. Methods: Parkinson's disease participants (n = 198) receiving functional magnetic resonance imaging from Parkinson's Progression Markers Initiative database were investigated. Participants were classified into lower quartile group (age rank: 0%similar to 25%), interquartile group (age rank: 26%similar to 75%), and upper quartile group (age rank: 76%similar to 100%) according to their age quartiles to examine how age shapes brain network topology. The differences of brain network topological properties between male and female participants were also investigated. Results: Parkinson's disease patients in the upper quartile age group exhibited disrupted network topology of white matter networks and impaired integrity of white matter fibers compared to lower quartile age group. In contrast, sex preferentially shaped the small-world topology of gray matter covariance network. Differential network metrics mediated the effects of age and sex on cognitive function of PD patients. Conclusion: Age and sex have diverse effects on brain structural networks and cognitive function of PD patients, highlighting their roles in the clinical management of PD.
引用
收藏
页码：1907 / 1922
页数：16
相关论文
共 69 条
[1]   Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson's disease [J].
Bakeberg, Megan C. ;
Gorecki, Anastazja M. ;
Kenna, Jade E. ;
Jefferson, Alexa ;
Byrnes, Michelle ;
Ghosh, Soumya ;
Horne, Malcolm K. ;
McGregor, Sarah ;
Stell, Rick ;
Walters, Sue ;
Chivers, Paola ;
Winter, Samantha J. ;
Mastaglia, Frank L. ;
Anderton, Ryan S. .
JOURNAL OF NEUROLOGY, 2021, 268 (05) :1903-1912
[2]   The anti-aging protein klotho alleviates injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine rat model of Parkinson's disease: Involvement of PKA/CaMKII/CREB signaling [J].
Baluchnejadmojarad, Tourandokht ;
Eftekhari, Seyed-Mohammad ;
Jamali-Raeufy, Nida ;
Haghani, Sobhan ;
Zeinali, Hossein ;
Roghani, Mehrdad .
EXPERIMENTAL GERONTOLOGY, 2017, 100 :70-76
[3]  
Barnish Max, 2019, Med J Islam Repub Iran, V33, P1, DOI 10.34171/mjiri.33.1
[4]   Normalization of similarity-based individual brain networks from gray matter MM and its association with neurodevelopment in infants with intrauterine growth restriction [J].
Batalle, Dafnis ;
Munoz-Moreno, Emma ;
Figueras, Francesc ;
Bargallo, Nuria ;
Eixarch, Elisenda ;
Gratacos, Eduard .
NEUROIMAGE, 2013, 83 :901-911
[5]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[6]   Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease [J].
Blauwendraat, Cornelis ;
Iwaki, Hirotaka ;
Makarious, Mary B. ;
Bandres-Ciga, Sara ;
Leonard, Hampton L. ;
Grenn, Francis P. ;
Lake, Julie ;
Krohn, Lynne ;
Tan, Manuela ;
Kim, Jonggeol J. ;
Gibbs, Jesse R. ;
Hernandez, Dena G. ;
Ruskey, Jennifer A. ;
Pihlstrom, Lasse ;
Toft, Mathias ;
van Hilten, Jacobus J. ;
Marinus, Johan ;
Schulte, Claudia ;
Brockmann, Kathrin ;
Sharma, Manu ;
Siitonen, Ari ;
Majamaa, Kari ;
Eerola-Rautio, Johanna ;
Tienari, Pentti J. ;
Grosset, Donald G. ;
Lesage, Suzanne ;
Corvol, Jean-Christophe ;
Brice, Alexis ;
Wood, Nick ;
Hardy, John ;
Gan-Or, Ziv ;
Heutink, Peter ;
Gasser, Thomas ;
Morris, Huw R. ;
Noyce, Alastair J. ;
Nalls, Mike A. ;
Singleton, Andrew B. .
ANNALS OF NEUROLOGY, 2021, 90 (01) :35-42
[7]   Gender-Related Vulnerability of Dopaminergic Neural Networks in Parkinson's Disease [J].
Boccalini, Cecilia ;
Carli, Giulia ;
Pilotto, Andrea ;
Padovani, Alessandro ;
Perani, Daniela .
BRAIN CONNECTIVITY, 2021, 11 (01) :3-11
[8]   Complex brain networks: graph theoretical analysis of structural and functional systems [J].
Bullmore, Edward T. ;
Sporns, Olaf .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) :186-198
[9]  
Carvalho de Abreu DC., 2023, LANCET, DOI [10.1111/ene.15692, DOI 10.1111/ENE.15692]
[10]   Scholastic performance and functional connectivity of brain networks in children [J].
Chaddock-Heyman, Laura ;
Weng, Timothy B. ;
Kienzler, Caitlin ;
Erickson, Kirk I. ;
Voss, Michelle W. ;
Drollette, Eric S. ;
Raine, Lauren B. ;
Kao, Shih-Chun ;
Hillman, Charles H. ;
Kramer, Arthur F. .
PLOS ONE, 2018, 13 (01)
1234567