Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury

被引：2
作者：
de Sousa, Nidia [1 ,2 ]
Robledo, Diego [3 ]
Gonzalez-Llera, Laura [4 ]
Pinho, Andreia G. [1 ,2 ]
Santos, Diogo J. [1 ,2 ]
Monteiro, Susana [1 ,2 ]
Campos, Jonas [1 ,2 ]
Cibrao, Jorge R. [1 ,2 ]
Silva, Nuno A. [1 ,2 ]
Sanchez, Laura [5 ,6 ]
Salgado, Antonio J. [1 ,2 ]
Barreiro-Iglesias, Anton [4 ]
机构：
[1] PT Govt Associated Lab, ICVS 3Bs Associate Lab, P-4806909 Braga, Portugal
[2] Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, P-4710057 Braga, Portugal
[3] Univ Edinburgh, Sch Vet Studies, Roslin Inst & Royal Dick, Edinburgh EH25 9RG, Midlothian, Scotland
[4] Univ Santiago De Compostela, Dept Funct Biol, Fac Biol, CIBUS, Santiago De Compostela 15782, Spain
[5] Univ Santiago Compostela, Dept Zool Genet & Phys Anthropol, Fac Vet Sci, Lugo 27002, Spain
[6] Hlth Res Inst Santiago De Compostela IDIS, Preclin Anim Models Grp, Santiago De Compostela 15706, Spain
来源：
DATA IN BRIEF | 2023年 / 46卷
关键词：
Baclofen; Spinal cord injury; RNA-seq; Traumatic nervous system injury; Neuroprotection; Regeneration;
D O I：
10.1016/j.dib.2022.108809
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments to promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can promote functional recovery after a compression SCI in mice [1] . Here, we provide tran-scriptomic (RNA-seq) data from adult mouse spinal cords collected 7 days after a compression SCI and baclofen (vs vehicle) administration. The Illumina NovaSeq 60 0 0 platform was used to generate the raw transcriptomic data. In addition, we also present bioinformatic analyses including differential gene expression analysis, enrichment analyses for various functional annotations (gene ontology, KEGG and BioCarta pathways or InterPro domains) and transcription factor targets. The raw RNA-seq data has been up-loaded to the NCBI Sequence Read Archive (SRA) database (Bioproject ID PRJNA886048). The data generated from the bioinformatic analyses is contained within the article. (c) 2022 The Author(s). Published by Elsevier Inc.
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页数：7
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