Antileishmanial anthraquinones from the rhyzomes of Rumex abyssinicus Jacq (Polygonaceae)

被引：5

作者：

Guetchueng, Stephanie Tamdem ^{[1
]}

Djouonzo, Paul Toukam ^{[1
]}

Lame, Younoussa ^{[2
]}

Kowa, Theodora Kopa ^{[1
,3
]}

Dotse, Eunice ^{[4
]}

Tchokouaha, Lauve R. Y. ^{[1
,5
]}

Wabo, Hippolyte Kamdem ^{[3
]}

Appiah-Opong, Regina ^{[4
]}

Agbor, Gabriel Agbor ^{[1
]}

机构：

[1] Inst Med Res & Med Plants Studies, Ctr Res Med Plants & Tradit Med, Yaounde, Cameroon

[2] Univ Yaounde I, Fac Sci, Dept Anim Biol & Physiol, Yaounde, Cameroon

[3] Univ Dschang, Fac Sci, Dept Chem, Nat Prod Chem Res Unit, Dschang, Cameroon

[4] Univ Ghana, Coll Hlth Sci CHS, Noguchi Mem Inst Med Res NMIMR, Dept Clin Pathol, Accra, Ghana

[5] Univ Ghana, Coll Hlth Sci CHS, Noguchi Mem Inst Med Res NMIMR, Dept Parasitol, Accra, Ghana

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 17期

关键词：

Rumex abyssinicus; anthraquinones; antileishmanial activity; LEISHMANIA; DISCOVERY;

D O I：

10.1080/14786419.2022.2137797

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-beta,D-glucopyranoside (4) and chrypsophanol-8-O-beta,D-glucopyranoside (5), and emodin-8-O-beta,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC50 13.82 and 0.26 mu g/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-beta,D-glucopyranoside (6) also showed a moderate activity with IC50 27.53 and 37.08 mu g/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.

引用

页码：2935 / 2939

页数：5

共 24 条

[21]

Tsamo LDF, 2021, Advances in Biological Chemistry, V11, P266, DOI 10.4236/abc.2021.115018

[22] HYDROXY-ANTHRAQUINONES AS ANTIMALARIAL AGENTS [J].

WINTER, RW ;

CORNELL, KA ;

JOHNSON, LL ;

ISABELLE, LM ;

HINRICHS, DJ ;

RISCOE, MK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (17) :1927-1932

[23]

Worku Netsanet, 2013, ISRN Biochem, V2013, P910308, DOI 10.1155/2013/910308

[24]

World Health Organization (WHO), 2021, Leishmaniasis, Key facts

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