Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study

被引:2
作者
Kalfon, Pierre [1 ,2 ,36 ]
El-Hage, Wissam [3 ,4 ]
Geantot, Marie-Agnes [5 ,7 ]
Favier, Constance [2 ]
Bodet-Contentin, Laetitia [6 ]
Kuteifan, Khaldoun [8 ]
Olivier, Pierre-Yves [9 ]
Thevenin, Didier [10 ]
Pottecher, Julien [11 ]
Crozon-Clauzel, Jullien [12 ]
Mauchien, Benedicte [1 ]
Galbois, Arnaud [13 ]
de Varax, Roland [14 ]
Valera, Sabine [15 ]
Estagnasie, Philippe [16 ]
Berric, Audrey [17 ]
Nyunga, Martine [18 ]
Revel, Nathalie [19 ]
Simon, Georges [20 ]
Kowalski, Benjamin [21 ]
Sossou, Achille [22 ]
Signouret, Thomas [23 ]
Leone, Marc [24 ]
Delale, Charles [25 ]
Seemann, Aurelien [26 ]
Lasocki, Sigismond [27 ]
Quenot, Jean-Pierre [28 ]
Monsel, Antoine [29 ]
Michel, Olivier [30 ]
Page, Mathieu [31 ]
Patrigeon, Rene-Gilles [32 ]
Nicola, Walid [33 ]
Thille, Arnaud W. [34 ]
Hekimian, Guillaume [35 ]
Auquier, Pascal [2 ]
Baumstarck, Karine [2 ]
机构
[1] Hop Louis Pasteur, Reanimat Polyvalente, CH Chartres, Le Coudray, France
[2] Aix Marseille Univ, Unite Rech, Aix Marseille, France
[3] Univ Tours, UMR 1253, iBrain, INSERM, Tours, France
[4] CHRU Tours, Ctr Reg Psychotraumatol, Tours, France
[5] CHU Dijon Bourgogne, Dept dAnesthesie Reanimat, Dijon, France
[6] CHRU Tours, Med Intens Reanimat, INSERM, CRICS TriGGERSep Network, Tours, France
[7] Univ Nantes & Tours, INSERM UMR1246 SPHERE, Tours, France
[8] Grp Hosp Reg Mulhouse Sud Alsace, Serv Reanimat Med, Mulhouse, France
[9] CHU Angers, Med Intens Reanimat, Angers, France
[10] CH Lens, Med Intens Reanimat, Lens, France
[11] Hop Hautepierre, CHU Strasbourg, Serv Anesthesie Reanimat & Med Peri Operat, Strasbourg, France
[12] Hosp Civils Lyon, Dept dAnesthesie Reanimat, CHU Edouard Herriot, Lyon, France
[13] Hop Prive Claude Galien, Serv Reanimat Polyvalente, Quincy Sou Senart, France
[14] CH Macon, Macon, GA, France
[15] Hop Nord Marseille, Assistance Publ Hop Marseille AP HM, Med Intens Reanimat, Marseille, France
[16] Clin Ambroise Pare, Neuilly Sur Seine, France
[17] Hop Sainte Musse, Reanimat Polyvalente, Toulon, France
[18] Hop Victor Provo, Reanimat Polyvalente, Roubaix, France
[19] Hop Louis Pasteur, CHU Nice, Reanimat Med Chirurg, Nice, France
[20] CH Troyes, Troyes, France
[21] CH Douai, Douai, France
[22] Hop Emile Roux, Dept Anesthesie Reanimat, Le Puy En Velay, France
[23] Hop Europeen Marseille, Marseille, France
[24] Hop Nord Marseille, APHM, Reanimat, Dept AnesthesieReanimat, Marseille, France
[25] Hop Simone Veil, CH Blois, Reanimat, Blois, Loir & Cher, France
[26] Nouvelle Clin Tours St Gatien, Tours, France
[27] CHU Angers, Reanimat Chirurg, Angers, France
[28] CHU Dijon Bourgogne, Serv Med Intens Reanimat, Dijon, France
[29] Sorbonne Univ, Hop Pitie Salpetriere, Assistance Publ Hop Paris APHP, Dept Anesthesie Reanimat, Paris, France
[30] CH Bourges, Serv Reanimat Polyvalente, Bourges, France
[31] Clin Convert, Bourg En Bresse, France
[32] CH Auxerre, Reanimat, Auxerre, France
[33] CH Montargis, Montargis, France
[34] CHU Poitiers, Med Intens Reanimat, Poitiers, France
[35] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Serv Med Intens Reanimat, Paris, France
[36] Hop Prive Casamance, Reanimat Polyvalente, 33 Blvd Farigoules, F-13400 Aubagne, France
关键词
Critical care; Posttraumatic stress disorder; COVID-19; Intensive care unit; INTENSIVE-CARE-UNIT; QUALITY-OF-LIFE; CRITICAL ILLNESS; PATIENTS RECOLLECTIONS; HOSPITAL ANXIETY; RISK-FACTORS; SYMPTOMS; EXPERIENCES; DEPRESSION; VALIDITY;
D O I
10.1186/s13054-024-04826-1
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
BackgroundPosttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the ICU for COVID-19 was stressful due to the severity of this disease. This study assessed whether admission to the ICU for COVID-19 was associated with a higher prevalence of PTSD compared with other causes of ICU admission after adjustment for pre-ICU psychological factors.MethodsThis prospective observational comparative cohort study included 31 ICUs. Eligible patients were adult ICU survivors hospitalized during the first wave of COVID-19 pandemic in France, regardless of the reason for admission. The prevalence of presumptive diagnosis of PTSD at 6 months was assessed using the PTSD Checklist for DSM-5 (PCL-5). Sociodemographics, clinical data, history of childhood trauma (Childhood Trauma Questionnaire [CTQ]), and exposure to potentially traumatic events (Life Events Checklist for DSM-5 [LEC-5]) were assessed.ResultsOf the 778 ICU survivors included during the first wave of COVID-19 pandemic in France, 417 and 361 were assigned to the COVID-19 and non-COVID-19 cohorts, respectively. Fourteen (4.9%) and 11 (4.9%), respectively, presented with presumptive diagnosis of PTSD at 6 months (p = 0.976). After adjusting for age, sex, severity score at admission, use of invasive mechanical ventilation, ICU duration, CTQ and LEC-5, COVID-19 status was not associated with presumptive diagnosis of PTSD using the PCL-5. Only female sex was associated with presumptive diagnosis of PTSD. However, COVID-19 patients reported significantly more intrusion and avoidance symptoms than non-COVID patients (39% vs. 29%, p = 0.015 and 27% vs. 19%, p = 0.030), respectively. The median PCL-5 score was higher in the COVID-19 than non-COVID-19 cohort (9 [3, 20] vs. 4 [2, 16], p = 0.034).ConclusionAdmission to the ICU for COVID-19 was not associated with a higher prevalence of PTSD compared with admission for another cause during the first wave of the COVID-19 pandemic in France. However, intrusion and avoidance symptoms were more frequent in COVID-19 patients than in non-COVID-19 patients.Trial Registration: Clinicaltrials.gov Identifier NCT03991611, registered on June 19, 2019.ConclusionAdmission to the ICU for COVID-19 was not associated with a higher prevalence of PTSD compared with admission for another cause during the first wave of the COVID-19 pandemic in France. However, intrusion and avoidance symptoms were more frequent in COVID-19 patients than in non-COVID-19 patients.Trial Registration: Clinicaltrials.gov Identifier NCT03991611, registered on June 19, 2019.
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