Successful treatment of nail lichen planus with tofacitinib: a case report and review of the literature

被引:5
作者
Huang, Jundong [1 ]
Shi, Wei [1 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Hu Nan Key Lab Aging Biol, Changsha, Peoples R China
关键词
nail lichen planus; tofacitinib; case report; review; JAK inhibitor;
D O I
10.3389/fmed.2023.1301123
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nail lichen planus (NLP) is a chronic inflammatory disease of unknown etiology and has been recognized as a nail potentially critical disorder, which can be severe and rapidly worsen with irreversible scarring. Currently, the treatment options are limited based on disease progression. High-potency topical or intralesional corticosteroids are commonly considered first-line therapeutic options; however, these therapies are unsuitable for all patients with NLP, especially those with extensive lesions. As a potential therapeutic target for inflammatory skin diseases, Janus kinase (JAK) inhibitors can suppress both type-1 and type-2 cytokines, thereby reducing the immune response and resultant inflammation. Recent studies have suggested benefit in cutaneous lichen planus and lichen planopilaris with oral JAK inhibitors. Here, we report a case of severe NLP that exhibited a favorable response to tofacitinib treatment. A 41-year-old woman presented to our clinic with a 2-year history of nail dystrophy of all fingers of both hands. The NLP was finally confirmed by histopathology and the above clinical features. After the informed consent signature, tofacitinib monotherapy, 5 mg twice a day, was then begun, and after 6 months, the appearance of her nails had a significant improvement.
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页数:5
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共 28 条
[1]   JAK-inhibitors in dermatology: current evidence and future applications [J].
Ciechanowicz, Piotr ;
Rakowska, Adriana ;
Sikora, Mariusz ;
Rudnicka, Lidia .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2019, 30 (07) :648-658
[2]   Mycophenolate Mofetil in the Treatment of Severe Corticosteroid-Dependent or Corticosteroid-Resistant Nail Lichen Planus: A Case Series of 5 Patients [J].
Duplaine, Alexandra ;
Cogrel, Olivier .
SKIN APPENDAGE DISORDERS, 2022, :427-430
[3]   JAK in the [Black] Box: A Dermatology Perspective on Systemic JAK Inhibitor Safety [J].
Elmariah, Sarina B. ;
Smith, Jeffrey S. ;
Merola, Joseph F. .
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2022, 23 (04) :427-431
[4]   Successful treatment of palmoplantar nail lichen planus with cyclosporine [J].
Florian, Butsch ;
Angelika, Jetter ;
Ernst, Schopf Rudolf .
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2014, 12 (08) :724-725
[5]   Nail lichen planus: A review of clinical presentation, diagnosis and therapy [J].
Grover, C. ;
Kharghoria, G. ;
Baran, R. .
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2022, 149 (03) :150-164
[6]   Review of Nail Lichen Planus Epidemiology, Pathogenesis, Diagnosis, and Treatment [J].
Gupta, Mohit Kumar ;
Lipner, Shari R. .
DERMATOLOGIC CLINICS, 2021, 39 (02) :221-230
[7]   Tofacitinib as Treatment for Nail Lichen Planus Associated With Alopecia Universalis [J].
Iorizzo, Matilde ;
Haneke, Eckart .
JAMA DERMATOLOGY, 2021, 157 (03) :352-353
[8]   Isolated nail lichen planus: An expert consensus on treatment of the classical form [J].
Iorizzo, Matilde ;
Tosti, Antonella ;
Starace, Michela ;
Baran, Robert ;
Daniel, C. Ralph, III ;
Di Chiacchio, Nilton ;
Goettmann, Sophie ;
Grover, Chander ;
Haneke, Eckart ;
Lipner, Shari R. ;
Rich, Phoebe ;
Richert, Bertrand ;
Rigopoulos, Dimitris ;
Rubin, Adam I. ;
Zaiac, Martin ;
Piraccini, Bianca Maria .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 83 (06) :1717-1723
[9]   Nail Lichen Planus: Successful Treatment with Etanercept [J].
Irla, N. ;
Schneiter, T. ;
Haneke, E. ;
Yawalkar, N. .
CASE REPORTS IN DERMATOLOGY, 2010, 2 (03) :173-176
[10]   JAK-inhibitors in dermatology - small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects [J].
Klein, Benjamin ;
Treudler, Regina ;
Simon, Jan C. .
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2022, 20 (01) :19-24