PHARMACOKINETICS AND PHARMACODYNAMICS OF METHOTREXATE POLYGLUTAMATE IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH LOW OR HIGH DOSE-METHOTREXATE IN COMBINATION WITH ADALIMUMAB: RESULTS FROM THE MIRACLE TRIAL

被引：0

作者：

Tamai, H. ^{[1
]}

Ikeda, K. ^{[2
]}

Miyamoto, T. ^{[3
]}

Taguchi, H. ^{[4
]}

Kuo, C. F. ^{[5
]}

Shin, K. ^{[6
]}

Hirata, S. ^{[7
]}

Okano, Y. ^{[8
]}

Sato, S. ^{[9
]}

Yasuoka, H. ^{[10
]}

Choi, I. A. ^{[11
]}

Park, S. H. ^{[12
]}

Weng, M. Y. ^{[13
]}

Kuwana, M. ^{[14
]}

Lee, Y. J. ^{[15
]}

Ishii, T. ^{[16
]}

Kim, J. ^{[17
]}

Kameda, H. ^{[18
]}

Kojima, T. ^{[19
,20
,21
]}

Baek, H. J. ^{[22
]}

Hsu, P. N. ^{[23
]}

Huang, C. M. ^{[24
]}

Cheng, T. T. ^{[25
,26
]}

Sung, W. Y. ^{[27
]}

Tsai, W. C. ^{[27
]}

Taninaga, T. ^{[28
]}

Mori, M. ^{[28
]}

Miyagishi, H. ^{[29
]}

Sato, Y. ^{[30
]}

Takeuchi, T. ^{[1
,31
]}

Kaneko, Y. ^{[1
]}

机构：

[1] Keio Univ, Div Rheumatol, Dept Internal Med, Sch Med, Tokyo, Japan

[2] Chiba Univ Hosp, Dept Allergy & Clin Immunol, Chiba, Japan

[3] Seirei Hamamatsu Gen Hosp, Dept Rheumatol, Hamamatsu, Shizuoka, Japan

[4] Kawasaki Municipal Kawasaki Hosp, Dept Internal Med, Kawasaki, Kanagawa, Japan

[5] Ctr Arthrit & Rheumat Dis, Kawasaki, Kanagawa, Japan

[6] Chang Gung Mem Hosp, Div Rheumatol Allergy & Immunol, Taoyuan, Taiwan

[7] Seoul Natl Univ, Div Rheumatol, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea

[8] Hiroshima Univ Hosp, Dept Clin Immunol & Rheumatol, Hiroshima, Japan

[9] Natl Hosp Org Tokyo Med Ctr, Div Rheumatol, Dept Med, Tokyo, Japan

[10] Tokai Univ, Div Rheumatol, Dept Internal Med, Sch Med, Isehara, Kanagawa, Japan

[11] Fujita Hlth Univ, Div Rheumatol, Dept Internal Med, Sch Med, Toyoake, Aichi, Japan

[12] Chungbuk Natl Univ, Dept Internal Med, Cheongju, South Korea

[13] Catholic Univ Korea, Seoul St Marys Hosp, Div Rheumatol, Dept Internal Med,Coll Med, Seoul, South Korea

[14] Natl Cheng Kung Univ Hosp, Natl Cheng Kung Univ, Div Allergy Immunol & Rheumatol, Dept Internal Med,Coll Med, Tainan, Taiwan

[15] Nippon Med Sch, Dept Allergy & Rheumatol, Grad Sch Med, Tokyo, Japan

[16] Seoul Natl Univ, Div Rheumatol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[17] Tohoku Univ Med, Clin Res Innovat & Educ Ctr, Sendai, Miyagi, Japan

[18] Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon, South Korea

[19] Toho Univ, Div Rheumatol, Dept Internal Med, Tokyo, Japan

[20] Natl Hosp Org Nagoya Med Ctr, Dept Orthoped Surg, Nagoya, Aichi, Japan

[21] Nagoya Univ, Dept Orthoped Surg, Grad Sch Med, Nagoya, Aichi, Japan

[22] Gachon Univ, Div Rheumatol, Dept Internal Med, Gil Med Ctr,Coll Med, Incheon, South Korea

[23] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[24] China Med Univ Hosp, Div Rheumatol & Immunol, Taichung, Taiwan

[25] Kaohsiung Chang Gung Mem Hosp, Taoyuan, Taiwan

[26] Chang Gung Univ, Sch Med, Div Rheumatol, Dept Internal Med,Coll Med, Taoyuan, Taiwan

[27] Kaohsiung Med Univ Hosp, Dept Allergy Immunol & Rheumatol, Kaohsiung, Taiwan

[28] Eisai & Co Ltd, Med Headquarters, Tokyo, Japan

[29] Eisai & Co Ltd, Clin Data Sci Dept, Tokyo, Japan

[30] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[31] Saitama Med Univ, Saitama, Japan

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2023年 / 82卷

关键词：

Rheumatoid arthritis; bDMARD;

D O I：

10.1136/annrheumdis-2023-eular.523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OP0128

引用

页码：84 / 85

页数：2