Lactobacillus casei ATCC 393 combined with vasoactive intestinal peptide alleviates dextran sodium sulfate-induced ulcerative colitis in C57BL/6 mice via NF-KB and Nrf2 signaling pathways

被引：14
作者：
Zhu, Lixu [1 ]
Qiao, Lei [1 ]
Dou, Xina [1 ]
Song, Xiaofan [1 ]
Chang, Jiajing [1 ]
Zeng, Xiaonan [1 ]
Xu, Chunlan [1 ,2 ]
机构：
[1] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China
[2] Northwestern Polytech Univ, Sch Life Sci, 127 Youyixi Rd, Xian 710072, Shaanxi, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷
基金：
中国国家自然科学基金;
关键词：
Lactobacillus casei ATCC 393; Vasoactive intestinal peptide; Ulcerative colitis; NF-KB; Nrf2; Gut microbiota; KAPPA-B; INHIBITION; PROBIOTICS; DISEASE; EXPRESSION; BACTERIA; INFLAMMATION; AUTOIMMUNE; MICROBIOTA; DAMAGE;
D O I：
10.1016/j.biopha.2023.115033
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) which is related to an immunological imbalance of the intestinal mucosa. Many clinical evidences indicate probiotics supplementation appears to be effective and safe in patients with UC. Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide with multiple physiological and pathological effects. In this study, we investigated the protective effect of the combination of Lactobacillus casei ATCC 393 (L. casei ATCC 393) with VIP on dextran sodium sulfate (DSS)-induced UC in mice and the potential mechanism. The results showed that, compared with the control group, DSS treatment significantly shortened the colon length, caused inflammation and oxidative stress, and further resulted in the intestinal barrier dysfunction and gut microbiota dysbiosis. In addition, intervention with L. casei ATCC 393, VIP or L. casei ATCC 393 combined with VIP significantly reduced UC disease activity index. However, compared with L. casei ATCC 393 or VIP, L. casei ATCC 393 combined with VIP effectively relieved symptoms of UC by regulating immune response, enhancing antioxidant capacity, and regulating nuclear factor kappa-B (NF-KB) and nuclear factor erythroid-derived-2-like 2 (Nrf2) signaling pathways. In conclusion, this study suggests that L. casei ATCC 393 combined with VIP can effectively relieve DSS-induced UC, which is a promising treatment strategy for UC.
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页数：15
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共 36 条
[31]   Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways [J].
Wang, Dongxu ;
Zhang, Man ;
Wang, Taotao ;
Liu, Tiantian ;
Guo, Yuanxin ;
Granato, Daniel .
FOOD AND CHEMICAL TOXICOLOGY, 2020, 144
[32]   Edible Bird's Nest Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in C57BL/6J Mice by Restoring the Th17/Treg Cell Balance [J].
Fan, Yaohua ;
Fan, Yanqun ;
Liu, Kunfeng ;
Lonan, Piyanuch ;
Liao, Feng ;
Huo, Yuhang ;
Zhong, Xiaohua ;
Liang, Yueliang ;
Wang, Yaxin ;
Hou, Shaozhen ;
Lai, Xiaoping ;
Li, Geng ;
Kuang, Weihong .
FRONTIERS IN PHARMACOLOGY, 2021, 12
[33]   Fermented and Germinated Processing Improved the Protective Effects of Foxtail Millet Whole Grain Against Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis and Gut Microbiota Dysbiosis in C57BL/6 Mice [J].
Zhang, Yuhan ;
Liu, Wei ;
Zhang, Di ;
Yang, Yanbing ;
Wang, Xianshu ;
Li, Lingfei .
FRONTIERS IN NUTRITION, 2021, 8
[34]   Human TFF2-Fc fusion protein alleviates DSS-induced ulcerative colitis in C57BL/6 mice by promoting intestinal epithelial cells repair and inhibiting macrophage inflammation [J].
Guo, Meng ;
Wang, Rongrong ;
Geng, Jiajia ;
Li, Zhen ;
Liu, Mingfei ;
Lu, Xuxiu ;
Wei, Jianteng ;
Liu, Ming .
INFLAMMOPHARMACOLOGY, 2023, 31 (03) :1387-1404
[35]   Human TFF2-Fc fusion protein alleviates DSS-induced ulcerative colitis in C57BL/6 mice by promoting intestinal epithelial cells repair and inhibiting macrophage inflammation [J].
Meng Guo ;
Rongrong Wang ;
Jiajia Geng ;
Zhen Li ;
Mingfei Liu ;
Xuxiu Lu ;
Jianteng Wei ;
Ming Liu .
Inflammopharmacology, 2023, 31 :1387-1404
[36]   Glycated Casein by TGase-Type Exerts Protection Potential against DSS-Induced Colitis via Inhibiting TLR4/NF-?B Signaling Pathways in C57BL/6J Mice [J].
Chu, Hui ;
Liu, Weiling ;
Zhao, Cong ;
Yin, Tong ;
Shi, Jia ;
Zhang, Wei .
FOODS, 2023, 12 (18)
1234