Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain

被引：19

作者：

Mintoff, Dillon ^{[1
,3
]}

Agius, Rachel ^{[2
,4
]}

Benhadou, Farida ^{[6
]}

Das, Anupam ^{[7
]}

Frew, John W. ^{[8
,9
,10
]}

Pace, Nikolai P. ^{[4
,5
]}

机构：

[1] Mater Dei Hosp, Dept Dermatol, Msida, Malta

[2] Mater Dei Hosp, Diabet & Endocrine Ctr, Msida, Malta

[3] Univ Malta, Fac Med & Surg, Dept Pathol, Msida, Malta

[4] Univ Malta, Fac Med & Surg, Msida, Malta

[5] Univ Malta, Ctr Mol Med & Biobanking, Msida, Malta

[6] Univ Libre Bruxelles, Hop Erasme, Dept Dermatol, Brussels, Belgium

[7] KPC Med Coll & Hosp, Dept Dermatol Venereol & Leprosy, Kolkata, India

[8] Ingham Inst Appl Med Res, Lab Translat Cutaneous Med, Sydney, NSW, Australia

[9] Liverpool Hosp, Dept Dermatol, Sydney, NSW, Australia

[10] Univ New South Wales, Sydney, NSW, Australia

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2023年 / 48卷 / 09期

关键词：

CROWN-LIKE STRUCTURES; ADIPOSE-TISSUE; WEIGHT; LIRAGLUTIDE; MAINTENANCE; PREVALENCE; MANAGEMENT; INDEX;

D O I：

10.1093/ced/llad182

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Hidradenitis suppurativa and obesity share a chronic, proinflammatory state. Patients with obesity and hidradenitis suppurativa may experience a particular phenotype and a worse prognosis than counterparts who are not obese. In this review, we scrutinize the relationship between hidradenitis suppurativa and obesity, and tackle obesity (and meta-inflammation) as a potential therapeutic target. Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of the pilosebaceous unit. The typical patient with HS is characterized as someone with obesity, who smokes and who has nodules, abscesses and/or draining tunnels predominantly distributed in intertriginous skin. It has been established that lifestyle and genetic factors are the main pathophysiological drivers of HS. In this critical review, we explore the interrelatedness of meta-inflammation, obesity and HS and discuss if and how this relationship may be manipulated for a therapeutic end.

引用

页码：984 / 990

页数：7

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