Prevalence and incidence of HEV among men using HIV pre-exposure prophylaxis: A sub-study of the ANRS IPERGAY trial

被引：9

作者：

Chaix, Marie-Laure ^{[19
,1
,2
]}

Leturque, Nicolas ^{[3
]}

Gabassi, Audrey ^{[1
]}

Charreau, Isabelle ^{[3
]}

Minier, Marine ^{[1
]}

Pialoux, Gilles ^{[4
]}

Cua, Eric ^{[5
]}

Chidiac, Christian ^{[6
]}

Raffi, Francois ^{[7
,8
]}

Tremblay, Cecile ^{[9
]}

Meyer, Laurence ^{[3
,10
]}

Molina, Jean-Michel ^{[2
,11
]}

Delaugerre, Constance ^{[1
,2
]}

机构：

[1] Hop St Louis, AP HP, Virol, Paris, France

[2] Univ Paris Cite, Hop St Louis, Inst Univ Hematol, INSERM,U944,CNRS,UMR 7212, F-75010 Paris, France

[3] INSERM SC10 US19, Villejuif, France

[4] Hop Tenon, AP HP, Malad Infect, Paris, France

[5] Ctr Hosp Nice, Malad Infect, Hop Archet, Paris, France

[6] Ctr Hosp & Univ Lyon, Malad Infect, Hop Croix Rousse, Lyon, France

[7] Univ Hosp Nantes, Dept Infect Dis, Nantes, France

[8] INSERM, CIC 1413, Nantes, France

[9] Ctr Hosp Univ Montreal, Malad Infect, Montreal, PQ, Canada

[10] Univ Paris Saclay, Univ Paris Sud, Paris, France

[11] Hop St Louis, AP HP, Malad Infect, Paris, France

来源：

JOURNAL OF CLINICAL VIROLOGY | 2023年 / 160卷

关键词：

HIV pre-exposure prophylaxis; Hepatitis E virus; Seroprevalence; Incidence; MSM; E VIRUS-INFECTION; SEX; SEROPREVALENCE; RISK;

D O I：

10.1016/j.jcv.2023.105380

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Men who have sex with men (MSM) have an increased risk of infection by pathogens transmitted by the oro-fecal route. Here, we investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in 416 MSM included in the ANRS IPERGAY PrEP trial.Results: Among the 62 (14.9% (95% CI: [11.6%-18.7%]) seropositive for HEV at inclusion, the only factor associated with testing seropositive for HEV was older age. Geographical origin, use of recreational drugs, number of sexual partners, status for HAV and bacterial sexually transmitted infection (STI) at inclusion were not associated. Among the 342 HEV-seronegative patients with available samples, 9 seroconverted after a median of follow-up of 2.1 years (IQR (interquartile range): [1.6; 3.0]).Conclusion: Overall, the HEV incidence was 1.19% per 100 person-years [95% CI: 0.54%; 2.26%]. Sexual transmission does not seem to be a major route of HEV infection in MSM, unlike HAV.

引用

页数：4

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