Pancreatic cancer: a glimmer of hope

被引：1

作者：

Nagendram, Sathyan ^{[1
,2
]}

Bhattacharya, Satyajit ^{[1
]}

机构：

[1] London Clin, HPB Surg Unit, London, England

[2] Barts Canc Inst, Ctr Tumour Biol, London, England

来源：

TRENDS IN UROLOGY & MENS HEALTH | 2023年 / 14卷 / 02期

关键词：

ADJUVANT CHEMOTHERAPY; GEMCITABINE; MANAGEMENT; FOLFIRINOX; RESECTION; SURGERY;

D O I：

10.1002/tre.904

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Pancreatic cancer carries a very poor prognosis, with five-year survival currently approaching 10%. Late presentation, lack of effective treatment options and a tumour microenvironment that subverts immune mechanisms are some of the reasons behind this. Here the authors discuss how advances in our understanding of tumour biology, identification and surveillance of high-risk groups, improvements in surgical outcomes and the availability of new chemotherapeutic options give us grounds for optimism.

引用

页码：5 / 10

页数：6

共 35 条

[1]

[Anonymous], About Us

[2] Update on the management of pancreatic cancer: Surgery is not enough [J].

Ansari, Daniel ;

Gustafsson, Adam ;

Andersson, Roland .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (11) :3157-3165

[3] A Phase II Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First-Line Treatment of Pancreatic Adenocarcinoma [J].

Benson, Al B., III ;

Wainberg, Zev A. ;

Hecht, J. Randolph ;

Vyushkov, Dmitry ;

Dong, Hua ;

Bendell, Johanna ;

Kudrik, Fred .

ONCOLOGIST, 2017, 22 (03) :241-+

[4]

Bhattacharya S., 2018, BAILEY LOVES SHORT P

[5] Cold Tumors: A Therapeutic Challenge for Immunotherapy [J].

Bonaventura, Paola ;

Shekarian, Tala ;

Alcazer, Vincent ;

Valladeau-Guilemond, Jenny ;

Valsesia-Wittmann, Sandrine ;

Amigorena, Sebastian ;

Caux, Christophe ;

Depil, Stephane .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[6] Prehabilitation prior to surgery for pancreatic cancer: A systematic review [J].

Bundred, James R. ;

Kamarajah, Sivesh K. ;

Hammond, John S. ;

Wilson, Colin H. ;

Prentis, James ;

Pandanaboyana, Sanjay .

PANCREATOLOGY, 2020, 20 (06) :1243-1250

[7]

Cancer Research UK, Pancreatic cancer statistics

[8] Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance? [J].

Ciernikova, Sona ;

Earl, Julie ;

Garcia Bermejo, Maria Laura ;

Stevurkova, Viola ;

Carrato, Alfredo ;

Smolkova, Bozena .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (11) :11-17

[9] FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer [J].

Conroy, T. ;

Hammel, P. ;

Hebbar, M. ;

Ben Abdelghani, M. ;

Wei, A. C. ;

Raoul, J. -L. ;

Chone, L. ;

Francois, E. ;

Artru, P. ;

Biagi, J. J. ;

Lecomte, T. ;

Assenat, E. ;

Faroux, R. ;

Ychou, M. ;

Volet, J. ;

Sauvanet, A. ;

Breysacher, G. ;

Di Fiore, F. ;

Cripps, C. ;

Kavan, P. ;

Texereau, P. ;

Bouhier-Leporrier, K. ;

Khemissa-Akouz, F. ;

Legoux, J. -L. ;

Juzyna, B. ;

Gourgou, S. ;

O'Callaghan, C. J. ;

Jouffroy-Zeller, C. ;

Rat, P. ;

Malka, D. ;

Castan, F. ;

Bachet, J. -B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (25) :2395-2406

[10] FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer [J].

Conroy, Thierry ;

Desseigne, Francoise ;

Ychou, Marc ;

Bouche, Olivier ;

Guimbaud, Rosine ;

Becouarn, Yves ;

Adenis, Antoine ;

Raoul, Jean-Luc ;

Gourgou-Bourgade, Sophie ;

de la Fouchardiere, Christelle ;

Bennouna, Jaafar ;

Bachet, Jean-Baptiste ;

Khemissa-Akouz, Faiza ;

Pere-Verge, Denis ;

Delbaldo, Catherine ;

Assenat, Eric ;

Chauffert, Bruno ;

Michel, Pierre ;

Montoto-Grillot, Christine ;

Ducreux, Michel .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19) :1817-1825

← 1 2 3 4 →