The value of magnetic resonance blood oxygen level-dependent imaging in evaluating the efficacy of advanced cervical cancer combined with radiotherapy and chemotherapy

被引:1
作者
Yin, Liang [1 ,2 ]
Zhuang, Xin [1 ]
Li, Jian-lin [1 ]
机构
[1] Lanzhou Univ, Hosp 1, Dept Radiol, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Dept Radiol, Hosp 1, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China
关键词
Magnetic resonance; blood oxygen level-dependent imaging; hypoxia function parameters; cervical cancer; radiotherapy and chemotherapy; efficacy evaluation; BOLD-MRI; HYPOXIA; TUMOR;
D O I
10.1177/02841851221130302
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background Blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is an imaging method used to analyze oxygenation status of the tumor. Purpose To investigate the feasibility of BOLD-MRI in evaluating the efficacy of advanced cervical cancer combined with radiotherapy and chemotherapy. Material and Methods This prospective study included 85 patients with advanced cervical cancer who received BOLD-MRI examination before and after concurrent chemoradiotherapy from October 2020 to December 2021. To investigate the changes of baseline R2* values and oR2* values of cervical cancers before and after treatment. Results 29 cases were complete response, 34 cases were partial response, and 22 cases showed progression. The baseline R2* values of the tumors were lower than that of the normal cervical muscle (P < 0.0001). After oxygen stimulation, the baseline R2* values of the tumors decreased (P = 0.012). After treatment, the baseline R2* values of the tumors increased (P = 0.007), and the dynamic oR2* values of the tumors decreased (P = 0.025). The baseline R2* value of the complete response was the highest (P = 0.000), the dynamic oR2* value of the complete response was the lowest (P = 0.017). Conclusion BOLD-MRI can evaluate the efficacy of concurrent chemoradiotherapy for advanced cervical cancer.
引用
收藏
页码:1668 / 1675
页数:8
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