Electrospun poly(D,L-lactic acid)/gelatin membrane using green solvent for absorbable periodontal tissue regeneration

被引：2
作者：
Jeong, Dayeon [1 ,2 ]
Jang, Juwoong [2 ]
Lee, Deuk Yong [1 ]
机构：
[1] Daelim Univ, Dept Biomed Engn, Anyang 13916, South Korea
[2] Renewmedical Co Ltd, R&D Ctr, Bucheon 14532, South Korea
来源：
JOURNAL OF THE KOREAN CRYSTAL GROWTH AND CRYSTAL TECHNOLOGY | 2023年 / 33卷 / 03期
关键词：
Absorbable periodontal tissue regeneration; Barrier membrane; Poly(D; L-lactic acid) (PDLLA); Gelatin; Electrospinning; Synthetic graft; MECHANICAL-PROPERTIES; NANOFIBROUS SCAFFOLD; BIOCOMPATIBILITY; FABRICATION;
D O I：
10.6111/JKCGCT.2022.33.3.104
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
Electrospinning was performed using an eco-friendly solvent composed of acetic acid, ethyl acetate and distilled water to investigate the effect of gelatin concentration on mechanical properties and cytotoxicity of absorbable poly(D,L-lactic acid) (PDLLA)/gelatin blend membrane. The tensile stress, strain at break, and WUC of the PDLLA/gelatin (97/3) scaffold at 26 wt% concentration were determined to be 3.9 +/- 0.7 MPa, 37 +/- 1.3 %, and 273 +/- 33 %, respectively. FT-IR results revealed that PDLLA and gelatin were bound only by van der Waals interactions. The cell viability of PDLLA/gelatin membranes containing 0 %, 1 %, 2 %, 3 %, and 4 % gelatin were more than 100 %, which makes all membranes highly suitable as a barrier membrane for absorbable periodontal tissue regeneration due to their marketed physical properties and biocompatibility.
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收藏
页码：104 / 109
页数：6
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