Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics

被引：0

作者：

Zhao, Ke ^{[1
]}

Vasquez, Joseph K. ^{[1
]}

Blackwell, Helen E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53562 USA

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 05期

关键词：

AUTOINDUCING PEPTIDES; RECEPTOR; ACTIVATION; VIRULENCE; ANALOGS;

D O I：

10.1039/d2cc05733f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Staphylococcus aureus uses small peptides to assess its population densisty (i.e., quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus.

引用

页码：587 / 590

页数：4

共 10 条

[1] Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
Georgia Karathanasi
Martin Saxtorph Bojer
Mara Baldry
Bárdur Andréson Johannessen
Sanne Wolff
Ines Greco
Mogens Kilstrup
Paul Robert Hansen
Hanne Ingmer
Scientific Reports, 8
[2] Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
Karathanasi, Georgia
Bojer, Martin Saxtorph
Baldry, Mara
Johannessen, Bardur Andreson
Wolff, Sanne
Greco, Ines
Kilstrup, Mogens
Hansen, Paul Robert
Ingmer, Hanne
SCIENTIFIC REPORTS, 2018, 8
[3] Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors
Vasquez, Joseph
Tal-Gan, Yftah
Cornilescu, Gabriel
Tyler, Kimberly A.
Blackwell, Helen
CHEMBIOCHEM, 2017, 18 (04) : 413 - 423
[4] Towards a pan-group activator of the quorum sensing system in the common pathogen Staphylococcus epidermidis
Shen, Wenqi
Tian, Yang
Blackwell, Helen E.
FASEB JOURNAL, 2018, 32 (01):
[5] Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed Through a Systematic Synthetic Study of the Group-III Autoinducing Peptide
Tal-Gan, Yftah
Stacy, Danielle M.
Foegen, Mary K.
Koenig, David W.
Blackwell, Helen E.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (21) : 7869 - 7882
[6] Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in Staphylococcus aureus
Zhang, LS
Lin, JQ
Ji, GY
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (19) : 19448 - 19456
[7] Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence
Nakagawa, Seitaro
Hillebrand, Greg G.
Nunez, Gabriel
ANTIBIOTICS-BASEL, 2020, 9 (04):
[8] THE PRIMARY STRUCTURE OF HUMAN-ERYTHROCYTE COPPER-ZINC SUPEROXIDE-DISMUTASE - CLEAVAGE WITH STAPHYLOCOCCUS-AUREUS PROTEASE, DETERMINATION OF THE N-TERMINAL BLOCKING GROUP AND LOCATION OF THE DISULFIDE BOND
MARTINI, F
SCHININA, ME
BANNISTER, WH
BANNISTER, JV
BARRA, D
ROTILIO, G
BOSSA, F
ITALIAN JOURNAL OF BIOCHEMISTRY, 1982, 31 (01): : 39 - 47
[9] Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability:: Interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of α-aminoacyl-L-cis-4,5-methanoprolinenitrile-based inhibitors
Magnin, DR
Robl, JA
Sulsky, RB
Augeri, DJ
Huang, YT
Simpkins, LM
Taunk, PC
Betebenner, DA
Robertson, JG
Abboa-Offei, BE
Wang, AY
Cap, M
Xin, L
Tao, L
Sitkoff, DF
Malley, MF
Gougoutas, JZ
Khanna, A
Huang, Q
Han, SP
Parker, RA
Hamann, LG
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (10) : 2587 - 2598
[10] Synthesis of novel potent DPP-IV inhibitors with enhanced chemical stability: Interplay between the alkyl fragment of the N-terminal amino acid moiety and the cyclopropyl group of alpha-aminoacyl-(L)-(cis)-4,5-methanoprolinenitrile-based inhibitors.
Magnin, D
Robl, J
Sulsky, RB
Augieri, DJ
Huang, Y
Taunk, P
Betebenner, DA
Simpkins, LM
Robertson, JG
Khanna, A
Abboa-Offei, B
Wang, AY
Cap, M
Xing, L
Tao, L
Sitkoff, D
Malley, M
Gougoutas, J
Huang, Q
Han, SP
Parker, RA
Hamann, LG
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U207 - U207

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