Dilemmas in the delivery of intravenous lipid emulsions and approach to hypertriglyceridemia in very preterm and low birth weight infants

被引：4
作者：
Frost, Brandy [1 ]
Martin, Camilia R. [2 ]
Calkins, Kara L. [3 ]
机构：
[1] Univ Chicago, Pritzker Sch Med, NorthShore Univ HealthSyst, Dept Pediat,Div Neonatol, Evanston, IL USA
[2] Weill Cornell Med, Div Neonatol, Dept Pediat, New York, NY USA
[3] UCLA, David Geffen Sch Med, Neonatal Res Ctr,Div Neonatol & Dev Biol, UCLA Childrens Discovery & Innovat Inst,Dept Pedi, Los Angeles, CA 90095 USA
来源：
JOURNAL OF PERINATOLOGY | 2023年 / 43卷 / 09期
关键词：
LIVER-DISEASE; FAILURE; ACID; GROWTH; TRIAL; CHILDREN; RATES;
D O I：
10.1038/s41372-023-01637-0
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Intravenous lipid emulsions (ILEs) are an essential component of parenteral nutrition for very preterm and very low birth weight infants (VLBWs). This article offers a perspective on advancements and controversies on ILE use in this population. ILEs prescribed after birth at a dose of 1.5-2 g/kg/day and advanced to 3 g/kg/day enhance growth. Growth appears to be similar for infants who receive an ILE composed of 100% soybean oil or a multi-oil ILE with 15% fish oil. 100% fish oil is the preferred ILE for the management of parenteral nutrition associated cholestasis and intestinal failure associated liver disease. Research is warranted to help determine how we can optimize ILEs to improve neurodevelopment and prematurity complications. Last, we lack a universal definition of hypertriglyceridemia (HTG) and consensus on triglyceride surveillance and HTG management. Investigation is required to determine the health impact of specific triglyceride ranges in very preterm infants and VLBWs.
引用
收藏
页码：1189 / 1193
页数：5
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