Mesenchymal stem cell-derived extracellular vesicles: emerging concepts in the treatment of spinal cord injury

被引：0
作者：
Wang, Shujun [1 ]
Du, Chengzhe [1 ]
Li, Guilan [2 ,3 ]
机构：
[1] Liaocheng Univ, Sch Phys Educ, Liaocheng, Shandong, Peoples R China
[2] Liaocheng Univ, Sch Life Sci, Liaocheng, Shandong, Peoples R China
[3] Liaocheng Univ, Sch Life Sci, 1 Hunan Rd, Liaocheng, Shandong, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2023年 / 15卷 / 07期
关键词：
Spinal cord injury; mesenchymal stem cells; extracellular vesicles; engineering; treatment; I COLLAGEN; EXOSOMES; ACTIVATION; EXPRESSION; SECRETION; RECOVERY; PATHWAY; PROTECT; BIOLOGY; REPAIR;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Spinal cord injury (SCI) is a prevalent central nervous system disease with a high disability rate, leading to the loss of motor and sensory nerve function. Due to the complex pathophysiology of SCI, more effective clinical treatment strategies are needed. Research has indicated the considerable potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) as a cell-free therapy in SCI repair and regeneration due to their ability to regulate immune cell activity and stimulate damaged neuron regeneration. Moreover, applying MSCs and engineered EVs can fully exploit the potential of MSC-EVs in spinal cord repair. Here, we outline the pathological process of SCI and its current clinical treatment status, summarize the latest MSC-EVs research and its pretreatment and engineering strategies in SCI treatment, and explore MSC-EVs application prospects.
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收藏
页码：4425 / 4438
页数：14
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