Mesenchymal stem cell-derived extracellular vesicles: emerging concepts in the treatment of spinal cord injury

被引：0

作者：

Wang, Shujun ^{[1
]}

Du, Chengzhe ^{[1
]}

Li, Guilan ^{[2
,3
]}

机构：

[1] Liaocheng Univ, Sch Phys Educ, Liaocheng, Shandong, Peoples R China

[2] Liaocheng Univ, Sch Life Sci, Liaocheng, Shandong, Peoples R China

[3] Liaocheng Univ, Sch Life Sci, 1 Hunan Rd, Liaocheng, Shandong, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2023年 / 15卷 / 07期

关键词：

Spinal cord injury; mesenchymal stem cells; extracellular vesicles; engineering; treatment; I COLLAGEN; EXOSOMES; ACTIVATION; EXPRESSION; SECRETION; RECOVERY; PATHWAY; PROTECT; BIOLOGY; REPAIR;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spinal cord injury (SCI) is a prevalent central nervous system disease with a high disability rate, leading to the loss of motor and sensory nerve function. Due to the complex pathophysiology of SCI, more effective clinical treatment strategies are needed. Research has indicated the considerable potential of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSC-EVs) as a cell-free therapy in SCI repair and regeneration due to their ability to regulate immune cell activity and stimulate damaged neuron regeneration. Moreover, applying MSCs and engineered EVs can fully exploit the potential of MSC-EVs in spinal cord repair. Here, we outline the pathological process of SCI and its current clinical treatment status, summarize the latest MSC-EVs research and its pretreatment and engineering strategies in SCI treatment, and explore MSC-EVs application prospects.

引用

页码：4425 / 4438

页数：14

共 116 条

[91] Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines [J].

Thery, Clotilde ;

Witwer, Kenneth W. ;

Aikawa, Elena ;

Jose Alcaraz, Maria ;

Anderson, Johnathon D. ;

Andriantsitohaina, Ramaroson ;

Antoniou, Anna ;

Arab, Tanina ;

Archer, Fabienne ;

Atkin-Smith, Georgia K. ;

Ayre, D. Craig ;

Bach, Jean-Marie ;

Bachurski, Daniel ;

Baharvand, Hossein ;

Balaj, Leonora ;

Baldacchino, Shawn ;

Bauer, Natalie N. ;

Baxter, Amy A. ;

Bebawy, Mary ;

Beckham, Carla ;

Zavec, Apolonija Bedina ;

Benmoussa, Abderrahim ;

Berardi, Anna C. ;

Bergese, Paolo ;

Bielska, Ewa ;

Blenkiron, Cherie ;

Bobis-Wozowicz, Sylwia ;

Boilard, Eric ;

Boireau, Wilfrid ;

Bongiovanni, Antonella ;

Borras, Francesc E. ;

Bosch, Steffi ;

Boulanger, Chantal M. ;

Breakefield, Xandra ;

Breglio, Andrew M. ;

Brennan, Meadhbh A. ;

Brigstock, David R. ;

Brisson, Alain ;

Broekman, Marike L. D. ;

Bromberg, Jacqueline F. ;

Bryl-Gorecka, Paulina ;

Buch, Shilpa ;

Buck, Amy H. ;

Burger, Dylan ;

Busatto, Sara ;

Buschmann, Dominik ;

Bussolati, Benedetta ;

Buzas, Edit, I ;

Byrd, James Bryan ;

Camussi, Giovanni .

JOURNAL OF EXTRACELLULAR VESICLES, 2018, 7 (01)

[92] Communication by Extracellular Vesicles: Where We Are and Where We Need to Go [J].

Tkach, Mercedes ;

Thery, Clotilde .

CELL, 2016, 164 (06) :1226-1232

[93] Effects of ganglioside GM1 and erythropoietin on spinal cord injury in mice: Functional and immunohistochemical assessments [J].

Torelli, Alessandro Gonzalez ;

Cristante, Alexandre Fogaca ;

Pessoa de Barros-Filho, Tarcisio Eloy ;

dos Santos, Gustavo Bispo ;

Morena, Beatriz Cintra ;

Correia, Felipe Fernandes ;

Paschon, Vera .

CLINICS, 2022, 77

[94] Mesenchymal stem cells in health and disease [J].

Uccelli, Antonio ;

Moretta, Lorenzo ;

Pistoia, Vito .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (09) :726-736

[95] Mammalian MSC from selected species: Features and applications [J].

Uder, Christiane ;

Brueckner, Sandra ;

Winkler, Sandra ;

Tautenhahn, Hans-Michael ;

Christ, Bruno .

CYTOMETRY PART A, 2018, 93A (01) :32-49

[96] Macrophage phagocytosis after spinal cord injury: when friends become foes [J].

Van Broeckhoven, Jana ;

Sommer, Daniela ;

Dooley, Dearbhaile ;

Hendrix, Sven ;

Franssen, Aimee J. P. M. .

BRAIN, 2021, 144 :2933-2945

[97] Challenges and directions in studying cell-cell communication by extracellular vesicles [J].

van Niel, Guillaume ;

Carter, David R. F. ;

Clayton, Aled ;

Lambert, Daniel W. ;

Raposo, Graca ;

Vader, Pieter .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2022, 23 (05) :369-382

[98] Shedding light on the cell biology of extracellular vesicles [J].

van Niel, Guillaume ;

D'Angelo, Gisela ;

Raposo, Graca .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018, 19 (04) :213-228

[99] Central nervous system regeneration [J].

Varadarajan, Supraja G. ;

Hunyara, John L. ;

Hamilton, Natalie R. ;

Kolodkin, Alex L. ;

Huberman, Andrew D. .

CELL, 2022, 185 (01) :77-94

[100] Targeted neurotechnology restores walking in humans with spinal cord injury [J].

Wagner, Fabien B. ;

Mignardot, Jean-Baptiste ;

Le Goff-Mignardot, Camille G. ;

Demesmaeker, Robin ;

Komi, Salif ;

Capogrosso, Marco ;

Rowald, Andreas ;

Seanez, Ismael ;

Caban, Miroslav ;

Pirondini, Elvira ;

Vat, Molywan ;

McCracken, Laura A. ;

Heimgartner, Roman ;

Fodor, Isabelle ;

Watrin, Anne ;

Seguin, Perrine ;

Paoles, Edoardo ;

Van Den Keybus, Katrien ;

Eberle, Gregoire ;

Schurch, Brigitte ;

Pralong, Etienne ;

Becce, Fabio ;

Prior, John ;

Buse, Nicholas ;

Buschman, Rik ;

Neufeld, Esra ;

Kuster, Niels ;

Carda, Stefano ;

von Zitzewitz, Joachim ;

Delattre, Vincent ;

Denison, Tim ;

Lambert, Hendrik ;

Minassian, Karen ;

Bloch, Jocelyne ;

Courtine, Gregoire .

NATURE, 2018, 563 (7729) :65-+

← 3 4 5 6 7 8 9 10 11 12 →