Recent Advances in Development of Metal-Organic Frameworks Based Extraction Approaches for Food and Biological Matrices

Food and human biological samples analysis are of great importance for human health. However, due to the complexity of sample matrices and low concentrations of target analytes, sample preparation is essentially critical for these samples through the whole analytical workflow. Metal-organic frameworks (MOFs), a class of synthesized functional nanomaterial, have been well recognized as novel adsorbents to enhance the sensitivity of current analytical methods and greatly assist the determination of potentially harmful substances present in food and biological samples. This critical review summarized the most advances in the applications of MOFs or hybrid MOFs as adsorbents for food and biological analysis in the past five years, particularly pertaining to sample preparation purpose including removal, adsorption, and enrichment of environmental contaminants. The synthetic routes and analytical performance of representative MOFs or MOFs composites are discussed. The limitations in preparation and application of reported MOFs adsorbents are discussed and the improvement methods for these limitations also have been concluded in the future perspectives.