In Vitro Profile of Hydrocortisone Release from Three-Dimensionally Printed Paediatric Mini-Tablets

被引:6
作者
Protopapa, Chrystalla [1 ]
Siamidi, Angeliki [1 ]
Kolipaka, Siva Satyanarayana [2 ]
Junqueira, Laura Andrade [2 ]
Douroumis, Dennis [2 ]
Vlachou, Marilena [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Sch Pharm, Dept Pharmaceut Technol, Athens 15784, Greece
[2] Univ Greenwich, Ctr Res Innovat, Medway Campus,Chatham Maritime, Chatham ME4 4TB, England
关键词
hydrocortisone; 3D printing; micro-extrusion; direct powder extrusion; paediatrics; drug formulation development; pharmaceutical technology; personalized medicine; Gelucire (R) 44/14; Precirol (R) ATO 5; CHILDREN;
D O I
10.3390/pharmaceutics16030385
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, the reduction in waste and the accelerated development of new formulations. In this study, micro-extrusion printing was implemented for the production of modified-release hydrocortisone (HCT) mini-tablets for paediatric patients. For the developed formulations, Gelucire (R) 44/14 and Precirol (R) ATO 5 were used as the main inks at three different ratios: 70%/30%, 60%/40% and 50%/50%, respectively. The printing parameters (temperature and pressure) were altered accordingly for each ratio to achieve printability. The printed mini-tablets exhibited excellent printing quality, featuring consistent layer thicknesses and smooth surfaces. Dissolution tests were performed, and the results indicated a successful modified release of HCT from the mini-tablets. In summary, micro-extrusion exhibited favourable processing abilities for powder blends, facilitating quick printing and the fabrication of potential personalized dosages.
引用
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页数:13
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