hydrocortisone;
3D printing;
micro-extrusion;
direct powder extrusion;
paediatrics;
drug formulation development;
pharmaceutical technology;
personalized medicine;
Gelucire (R) 44/14;
Precirol (R) ATO 5;
CHILDREN;
D O I:
10.3390/pharmaceutics16030385
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, the reduction in waste and the accelerated development of new formulations. In this study, micro-extrusion printing was implemented for the production of modified-release hydrocortisone (HCT) mini-tablets for paediatric patients. For the developed formulations, Gelucire (R) 44/14 and Precirol (R) ATO 5 were used as the main inks at three different ratios: 70%/30%, 60%/40% and 50%/50%, respectively. The printing parameters (temperature and pressure) were altered accordingly for each ratio to achieve printability. The printed mini-tablets exhibited excellent printing quality, featuring consistent layer thicknesses and smooth surfaces. Dissolution tests were performed, and the results indicated a successful modified release of HCT from the mini-tablets. In summary, micro-extrusion exhibited favourable processing abilities for powder blends, facilitating quick printing and the fabrication of potential personalized dosages.
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Programa Doctorado Ciencias Med & Farmaceuticas, Desarrollo & Calidad Vida, San Cristobal la Laguna 38200, Tenerife, Spain
Consejeria Econ, Conocimiento & Empleo, San Cristobal la Laguna, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Eduardo, Diaz-Torres
Ana, Santovena-Estevez
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Ana, Santovena-Estevez
Jose, B. Farin
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
机构:
FabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England
Univ Santiago de Compostela, R D Pharma Grp GI 1645, Dept Farmacol Farm & Tecnol Farmaceut, Santiago De Compostela 15782, SpainFabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Programa Doctorado Ciencias Med & Farmaceuticas, Desarrollo & Calidad Vida, San Cristobal la Laguna 38200, Tenerife, Spain
Consejeria Econ, Conocimiento & Empleo, San Cristobal la Laguna, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Eduardo, Diaz-Torres
Ana, Santovena-Estevez
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Ana, Santovena-Estevez
Jose, B. Farin
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal la Laguna 38206, SpainUniv La Laguna, Fac Farm, San Cristobal la Laguna 38206, Spain
机构:
FabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England
Univ Santiago de Compostela, R D Pharma Grp GI 1645, Dept Farmacol Farm & Tecnol Farmaceut, Santiago De Compostela 15782, SpainFabRx Ltd, 3 Romney Rd, Ashford TN24 0RW, Kent, England