Pilot study on the effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on body composition in children with acute lymphoblastic leukemia: randomized clinical trial

被引：6

作者：

Barbosa-Cortes, Lourdes ^{[1
]}

Martinez-Vieyra, Ximena ^{[1
]}

Mejia-Arangure, Juan Manuel ^{[2
,3
]}

Lopez-Alarcon, Mardia ^{[1
]}

Martin-Trejo, Jorge ^{[4
]}

Delgadillo-Portillo, Suily ^{[1
]}

Guzman-Castro, Brenda ^{[1
]}

Delgadillo-Portillo, Jazmin ^{[1
]}

Atilano-Miguel, Salvador ^{[1
]}

Rodriguez-Cruz, Maricela ^{[1
]}

Maldonado-Hernandez, Jorge ^{[1
]}

Anoveros-Barrera, Ana ^{[1
]}

Solis-Labastida, Karina A. ^{[4
]}

Espinoza-Hernandez, Laura ^{[5
]}

Nunez-Villegas, Nora N. ^{[5
]}

Jimenez-Hernandez, Elva ^{[5
]}

Bautista-Martinez, Benito A. ^{[4
]}

Juarez-Moya, Azalia ^{[4
]}

Hernandez-Pinon, Zayra ^{[4
]}

Perez-Casillas, Ruy Xavier ^{[5
]}

机构：

[1] Inst Mexicano Seguro Social IMSS, Unidad Invest Med Nutr, Unidad Med Alta Especialidad UMAE, Ctr Med Nacl Siglo XXI,Hosp Pediat, Ciudad De Mexico, Mexico

[2] Inst Nacl Med Genom, Lab Genom Canc, Ciudad De Mexico, Mexico

[3] Univ Nacl Autonoma Mexico, Fac Med, Ciudad De Mexico, Mexico

[4] Inst Mexicano Seguro Social IMSS, Serv Hematol, Unidad Med Alta Especialidad UMAE, Hosp Pediat,Ctr Med Nacl Siglo XXI, Ciudad De Mexico, Mexico

[5] Inst Mexicano Seguro Social IMSS, Dept Hematol Pediat, Unidad Med Alta Especialidad UMAE, Ctr Med Nacl La Raza, Ciudad De Mexico, Mexico

来源：

CLINICAL NUTRITION | 2023年 / 42卷 / 09期

关键词：

Body composition; Lean body mass; n-3 polyunsaturated fatty acids (LCPUFA-omega 3); EPA; DHA; Acute lymphoblastic leukemia; Children; CELL LUNG-CANCER; EICOSAPENTAENOIC ACID; FISH-OIL; NUTRITIONAL SUPPLEMENT; WEIGHT-LOSS; MASS; INTERVENTION; THERAPY; PROTEIN; CHEMOTHERAPY;

D O I：

10.1016/j.clnu.2023.06.022

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: N-3 polyunsaturated fatty acids (LCPUFA-omega 3), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) might have beneficial effects on lean mass and fat mass synthesis. Objective: To investigate the effect of LCPUFA-omega 3 supplementation on body composition changes in children with acute lymphoblastic leukemia (ALL) at remission and three months (3 mo) after supplementation. Methods: This randomized controlled trial enrolled 72 children (3e13 y) with newly diagnosed ALL (placebo group [500 mg sunflower oil]: 36 patients; LCPUFA-omega 3 group [225 mg DHA, 45 mg EPA]: 36 patients). LCPUFA-omega 3 was administered at 0.100 g/kg of body weight/day for 3 mo. Both groups were provided with an oral milkshake supplement. Main outcomes and measures: Body composition was measured at diagnosis, remission, and 3 months after supplementation by dual-energy X-ray absorptiometry (DXA). Red blood cell fatty acid analyses were performed with gas chromatography. Student's t test compared the percentage changes in body weight, total body fat percentage (TBFP), and lean body mass (LBM) between the groups. The Mann-Whitney U test was used to compare the groups, and the Friedman range test and Wilcoxon signed rank test were used for intratreatment comparisons. Spearman correlation coefficients were calculated for LBM and erythrocyte LCPUFA-omega 3 content. Results: LBM decreased significantly in both groups. This loss was greater in the placebo group than in the LCPUFA-omega 3 group at remission (p = 0.044) and at 3 months of supplementation (p = 0.039). There were significant and progressive increases in DHA and EPA concentrations in the LCPUFA-omega 3 group (p < 0.001). LBM at remission was directly correlated with increased DHA (r = 0.487, p = 0.034) and EPA (r = 0.499, p = 0.030) erythrocytes in the LCPUFA-omega 3 group. Conclusion: At ALL diagnosis and during the first three months of treatment, 100 mg/kg of body weight/d DHA and EPA decreased LBM loss and allowed the incorporation of fatty acids into cell membranes. (c) 2023 Published by Elsevier Ltd.

引用

页码：1759 / 1769

页数：11

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