Multifaceted mitochondrial quality control in brown adipose tissue

被引：23

作者：

Aquilano, Katia ^{[1
]}

Zhou, Beiyan ^{[2
,3
]}

Brestoff, Jonathan R. ^{[4
]}

Lettieri-Barbato, Daniele ^{[1
,5
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[2] Univ Connecticut, Dept Immunol, Sch Med, Farmington, CT 06030 USA

[3] Univ Connecticut, Inst Syst Genom, Farmington, CT 06030 USA

[4] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

[5] Fdn Santa Lucia, IRCCS, I-00179 Rome, Italy

来源：

TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ALTERNATIVELY ACTIVATED MACROPHAGES; INSULIN-RESISTANCE; PATHWAY; OBESITY; THERMOGENESIS; ADIPOCYTES; AUTOPHAGY; DELETION; CATECHOLAMINES; REGENERATION;

D O I：

10.1016/j.tcb.2022.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity of BAT is subject to cycles of activation and deactivation in response to environmental temperature changes, an integrated mitochondrial quality control (MQC) system is of fundamental importance to ensure BAT physiology. Here, we provide an overview of the conventional and alternative mechanisms through which thermogenic adipocytes selectively remove damaged parts of mitochondria and how macrophages participate in the MQC system by removing extracellular mitochondrial waste to maintain the thermogenic function of BAT. © 2022 Elsevier Ltd

引用

页码：517 / 529

页数：13

共 95 条

[1] Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance [J].

Altshuler-Keylin, Svetlana ;

Shinoda, Kosaku ;

Hasegawa, Yutaka ;

Ikeda, Kenji ;

Hong, Haemin ;

Kang, Qianqian ;

Yang, Yangyu ;

Perera, Rushika M. ;

Debnath, Jayanta ;

Kajimura, Shingo .

CELL METABOLISM, 2016, 24 (03) :402-419

[2] Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue [J].

Aquilano, Katia ;

Sciarretta, Francesca ;

Turchi, Riccardo ;

Li, Bo-Han ;

Rosina, Marco ;

Ceci, Veronica ;

Guidobaldi, Giulio ;

Arena, Simona ;

D'Ambrosio, Chiara ;

Audano, Matteo ;

Salvatori, Illari ;

Colella, Barbara ;

Faraonio, Raffaella ;

Panebianco, Concita ;

Pazienza, Valerio ;

Caruso, Donatella ;

Mitro, Nico ;

Di Bartolomeo, Sabrina ;

Scaloni, Andrea ;

Li, Jing-Ya ;

Lettieri-Barbato, Daniele .

REDOX BIOLOGY, 2020, 36

[3] Adipose Tissue Remodeling in Pathophysiology [J].

Auger, Christopher ;

Kajimura, Shingo .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2023, 18 :71-93

[4] Dietary fat overload reprograms brown fat mitochondria [J].

Barbato, Daniele Lettieri ;

Tatulli, Giuseppe ;

Vegliante, Rolando ;

Cannata, Stefano M. ;

Bernardini, Sergio ;

Ciriolo, Maria R. ;

Aquilano, Katia .

FRONTIERS IN PHYSIOLOGY, 2015, 6

[5] Glutathione Decrement Drives Thermogenic Program In Adipose Cells [J].

Barbato, Daniele Lettieri ;

Tatulli, Giuseppe ;

Cannata, Stefano Maria ;

Bernardini, Sergio ;

Aquilano, Katia ;

Ciriolo, Maria R. .

SCIENTIFIC REPORTS, 2015, 5

[6] Brown adipose tissue activity controls triglyceride clearance [J].

Bartelt, Alexander ;

Bruns, Oliver T. ;

Reimer, Rudolph ;

Hohenberg, Heinz ;

Ittrich, Harald ;

Peldschus, Kersten ;

Kaul, Michael G. ;

Tromsdorf, Ulrich I. ;

Weller, Horst ;

Waurisch, Christian ;

Eychmueller, Alexander ;

Gordts, Philip L. S. M. ;

Rinninger, Franz ;

Bruegelmann, Karoline ;

Freund, Barbara ;

Nielsen, Peter ;

Merkel, Martin ;

Heeren, Joerg .

NATURE MEDICINE, 2011, 17 (02) :200-U93

[7] The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites [J].

Bean, Camilla ;

Audano, Matteo ;

Varanita, Tatiana ;

Favaretto, Francesca ;

Medaglia, Marta ;

Gerdol, Marco ;

Pernas, Lena ;

Stasi, Fabio ;

Giacomello, Marta ;

Herkenne, Stephanie ;

Muniandy, Maheswany ;

Heinonen, Sini ;

Cazaly, Emma ;

Ollikainen, Miina ;

Milan, Gabriella ;

Pallavicini, Alberto ;

Pietilainen, Kirsi H. ;

Vettor, Roberto ;

Mitro, Nico ;

Scorrano, Luca .

NATURE METABOLISM, 2021, 3 (12) :1633-+

[8] Brown adipose tissue is associated with cardiometabolic health [J].

Becher, Tobias ;

Palanisamy, Srikanth ;

Kramer, Daniel J. ;

Eljalby, Mahmoud ;

Marx, Sarah J. ;

Wibmer, Andreas G. ;

Butler, Scott D. ;

Jiang, Caroline S. ;

Vaughan, Roger ;

Schoeder, Heiko ;

Mark, Allyn ;

Cohen, Paul .

NATURE MEDICINE, 2021, 27 (01) :58-+

[9] Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men [J].

Blondin, Denis P. ;

Tingelstad, Hans C. ;

Noll, Christophe ;

Frisch, Frederique ;

Phoenix, Serge ;

Guerin, Brigitte ;

Turcotte, Eric E. ;

Richard, Denis ;

Haman, Francois ;

Carpentier, Andre C. .

Nature Communications, 2017, 8

[10] Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood [J].

Borcherding, Nicholas ;

Jia, Wentong ;

Giwa, Rocky ;

Field, Rachael L. ;

Moley, John R. ;

Kopecky, Benjamin J. ;

Chan, Mandy M. ;

Yang, Bin Q. ;

Sabio, Jessica M. ;

Walker, Emma C. ;

Osorio, Omar ;

Bredemeyer, Andrea L. ;

Pietka, Terri ;

Alexander-Brett, Jennifer ;

Morley, Sharon Celeste ;

Artyomov, Maxim N. ;

Abumrad, Nada A. ;

Schilling, Joel ;

Lavine, Kory ;

Crewe, Clair ;

Brestoff, Jonathan R. .

CELL METABOLISM, 2022, 34 (10) :1499-+

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