Multifaceted mitochondrial quality control in brown adipose tissue

被引：18
作者：
Aquilano, Katia [1 ]
Zhou, Beiyan [2 ,3 ]
Brestoff, Jonathan R. [4 ]
Lettieri-Barbato, Daniele [1 ,5 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[2] Univ Connecticut, Dept Immunol, Sch Med, Farmington, CT 06030 USA
[3] Univ Connecticut, Inst Syst Genom, Farmington, CT 06030 USA
[4] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA
[5] Fdn Santa Lucia, IRCCS, I-00179 Rome, Italy
来源：
TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 06期
基金：
美国国家卫生研究院;
关键词：
ALTERNATIVELY ACTIVATED MACROPHAGES; INSULIN-RESISTANCE; PATHWAY; OBESITY; THERMOGENESIS; ADIPOCYTES; AUTOPHAGY; DELETION; CATECHOLAMINES; REGENERATION;
D O I：
10.1016/j.tcb.2022.09.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity of BAT is subject to cycles of activation and deactivation in response to environmental temperature changes, an integrated mitochondrial quality control (MQC) system is of fundamental importance to ensure BAT physiology. Here, we provide an overview of the conventional and alternative mechanisms through which thermogenic adipocytes selectively remove damaged parts of mitochondria and how macrophages participate in the MQC system by removing extracellular mitochondrial waste to maintain the thermogenic function of BAT. © 2022 Elsevier Ltd
引用
收藏
页码：517 / 529
页数：13
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