Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review

被引:9
作者
Pei, Xue-Bin [1 ]
Liu, Bo [2 ]
机构
[1] Capital Med Univ, Beijing Chao Yang Hosp, Emergency Med Clin Res Ctr, Beijing 100020, Peoples R China
[2] Capital Med Univ, Beijing YouAn Hosp, Dept Emergency Med, Beijing 100069, Peoples R China
关键词
INDUCED MYOCARDIAL DYSFUNCTION; VENTRICULAR DIASTOLIC DYSFUNCTION; COMPLEMENT-INDUCED ACTIVATION; BRAIN NATRIURETIC PEPTIDE; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; GROUP BOX 1; SEVERE SEPSIS; MITOCHONDRIAL DYSFUNCTION; ORGAN DYSFUNCTION;
D O I
10.1155/2023/8107336
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Sepsis is defined as a kind of life-threatening organ dysfunction due to a dysregulated host immune response to infection and is a leading cause of mortality in the intensive care unit. Sepsis-induced myocardial dysfunction, also called septic cardiomyopathy, is a common and serious complication in patients with sepsis, which may indicate a bad prognosis. Although efforts have been made to uncover the pathophysiology of septic cardiomyopathy, a number of uncertainties remain. This article sought to review available literature to summarize the existing knowledge on current diagnostic tools and biomarkers, pathogenesis, and treatments for septic cardiomyopathy.
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页数:14
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共 147 条
[1]   Selective NOS inhibition restores myocardial contractility in endotoxemic rats; However, myocardial NO content does not correlate with myocardial dysfunction [J].
Afulukwe, IF ;
Cohen, RI ;
Zeballos, GA ;
Iqbal, M ;
Scharf, SM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (01) :21-26
[2]   Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis [J].
Akoumianaki, Tonia ;
Vaporidi, Katerina ;
Diamantaki, Eleni ;
Pene, Frederic ;
Beau, Remi ;
Gresnigt, Mark S. ;
Gkountzinopulou, Marina ;
Venichaki, Maria ;
Drakos, Elias ;
El-Benna, Jamel ;
Samonis, George ;
Le, Kieu T. T. ;
Kumar, Vinod ;
Georgopoulos, Dimitrios ;
van de Veerdonk, Frank L. ;
Netea, Mihai G. ;
Latge, Jean-Paul ;
Chamilos, Georgios .
CELL HOST & MICROBE, 2021, 29 (08) :1277-+
[3]   Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis [J].
Alhamdi, Yasir ;
Abrams, Simon T. ;
Cheng, Zhenxing ;
Jing, Shengjie ;
Su, Dunhao ;
Liu, Zhiyong ;
Lane, Steven ;
Welters, Ingeborg ;
Wang, Guozheng ;
Toh, Cheng-Hock .
CRITICAL CARE MEDICINE, 2015, 43 (10) :2094-2103
[4]   Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial [J].
Antcliffe, David B. ;
Santhakumaran, Shalini ;
Orme, Robert M. L. ;
Ward, Josie K. ;
Al-Beidh, Farah ;
O'Dea, Kieran ;
Perkins, Gavin D. ;
Singer, Mervyn ;
McAuley, Daniel F. ;
Mason, Alexina J. ;
Cross, Mary ;
Ashby, Deborah ;
Gordon, Anthony C. .
INTENSIVE CARE MEDICINE, 2019, 45 (10) :1392-1400
[5]   Septic Cardiomyopathy [J].
Beesley, Sarah J. ;
Weber, Gerhard ;
Sarge, Todd ;
Nikravan, Sara ;
Grissom, Colin K. ;
Lanspa, Michael J. ;
Shahul, Sajid ;
Brown, Samuel M. .
CRITICAL CARE MEDICINE, 2018, 46 (04) :625-634
[6]   The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection [J].
Bernardi, Paolo ;
Di Lisa, Fabio .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 78 :100-106
[7]   Prognostic value of troponins in sepsis: a meta-analysis [J].
Bessiere, Francis ;
Khenifer, Safia ;
Dubourg, Julie ;
Durieu, Isabelle ;
Lega, Jean-Christophe .
INTENSIVE CARE MEDICINE, 2013, 39 (07) :1181-1189
[8]   Left ventricular systolic dysfunction during septic shock: the role of loading conditions [J].
Boissier, Florence ;
Razazi, Keyvan ;
Seemann, Aurelien ;
Bedet, Alexandre ;
Thille, Arnaud W. ;
de Prost, Nicolas ;
Lim, Pascal ;
Brun-Buisson, Christian ;
Dessap, Armand Mekontso .
INTENSIVE CARE MEDICINE, 2017, 43 (05) :633-642
[9]   Acute left ventricular dilatation and shock-induced myocardial dysfunction [J].
Bouhemad, Belaid ;
Nicolas-Robin, Armelle ;
Arbelot, Charlotte ;
Arthaud, Martine ;
Feger, Frederic ;
Rouby, Jean-Jacques .
CRITICAL CARE MEDICINE, 2009, 37 (02) :441-447
[10]   Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure [J].
Brealey, D ;
Karyampudi, S ;
Jacques, TS ;
Novelli, M ;
Stidwill, R ;
Taylor, V ;
Smolenski, RT ;
Singer, M .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 286 (03) :R491-R497