Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases

被引：9

作者：

Wen, Tingting ^{[1
]}

Zhang, Zhaohui ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷

基金：

新加坡国家研究基金会;

关键词：

fibrinogen; fibrin; CNS; neurodegenerative disease; AD; MS; BLOOD-BRAIN-BARRIER; MULTIPLE-SCLEROSIS LESIONS; GAMMA-C-DOMAIN; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; MOUSE MODEL; INTEGRIN ALPHA(M)BETA(2); CEREBRAL HYPOPERFUSION; INFLAMMATORY RESPONSE; HUNTINGTONS-DISEASE;

D O I：

10.3389/fnins.2023.1197094

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodegenerative diseases are prevalent and currently incurable conditions that progressively impair cognitive, behavioral, and psychiatric functions of the central or peripheral nervous system. Fibrinogen, a macromolecular glycoprotein, plays a crucial role in the inflammatory response and tissue repair in the human body and interacts with various nervous system cells due to its unique molecular structure. Accumulating evidence suggests that fibrinogen deposits in the brains of patients with neurodegenerative diseases. By regulating pathophysiological mechanisms and signaling pathways, fibrinogen can exacerbate the neuro-pathological features of neurodegenerative diseases, while depletion of fibrinogen contributes to the amelioration of cognitive function impairment in patients. This review comprehensively summarizes the molecular mechanisms and biological functions of fibrinogen in central nervous system cells and neurodegenerative diseases, including Alzheimer's disease, Multiple Sclerosis, Parkinson's disease, Vascular dementia, Huntington's disease, and Amyotrophic Lateral Sclerosis. Additionally, we discuss the potential of fibrinogen-related treatments in the management of neurodegenerative disorders.

引用

页数：13

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