Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries

被引：6
作者：
Zhu, Zeshu [1 ]
Zhu, Ping [2 ,3 ]
Fan, Xiongwei [1 ]
Mo, Xiaoyang [1 ]
Wu, Xiushan [1 ,3 ]
机构：
[1] Hunan Normal Univ, Coll Life Sci, Ctr Heart Dev, State Key Lab Dev Biol Freshwater Fish, Changsha, Hunan, Peoples R China
[2] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China
[3] Guangdong Prov Key Lab Pathogenesis Targeted Preve, Guangzhou, Guangdong, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
mesenchymal stem cells; exosomes; non-coding RNA; miRNA; heart injury; INHIBIT CARDIOMYOCYTE APOPTOSIS; STROMAL CELLS; MYOCARDIAL-INFARCTION; CIRCULATING MICRORNA; NONCODING RNAS; ANGIOGENESIS; ISCHEMIA; PROMOTES; FAILURE; PROTECTS;
D O I：
10.3389/fcell.2023.1093113
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mesenchymal stem cells (MSCs) are one of the most potent therapeutic strategies for repairing cardiac injury. It has been shown in the latest studies that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may dominate the repair of heart injury and promote the restoration of cardiac cells, vascular proliferation, immune regulation, etc. Based on the current research, the progress of the acting mechanism, application prospects and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries are summarised in this article.
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收藏
页数：16
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