Menthol: An underestimated anticancer agent

被引:21
作者
Zhao, Yijia [1 ]
Pan, Huafeng [2 ]
Liu, Wei [3 ]
Liu, E. [1 ]
Pang, Yaobin [1 ]
Gao, Hongjin [1 ]
He, Qingying [1 ]
Liao, Wenhao [1 ]
Yao, Yejing [1 ]
Zeng, Jinhao [4 ,5 ]
Guo, Jing [1 ]
机构
[1] Hosp Chengdu Univ Tradit Chinese Med, Dermatol Dept, Chengdu, Peoples R China
[2] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China
[4] Hosp Chengdu Univ Tradit Chinese Med, Dept Gastroenterol, Chengdu, Peoples R China
[5] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China
基金
中国国家自然科学基金;
关键词
anticancer; menthol; natural product; molecular mechanism; future direction; EARLY GASTRIC-CANCER; PEPPERMINT OIL; CELL-CYCLE; TRPM8; CHANNEL; SMOOTH-MUSCLE; PC-3; CELLS; PROLIFERATION; LUNG; ANGIOGENESIS; (-)-MENTHOL;
D O I
10.3389/fphar.2023.1148790
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Menthol, a widely used natural, active compound, has recently been shown to have anticancer activity. Moreover, it has been found to have a promising future in the treatment of various solid tumors. Therefore, using literature from PubMed, EMBASE, Web of Science, Ovid, ScienceDirect, and China National Knowledge Infrastructure databases, the present study reviewed the anticancer activity of menthol and the underlying mechanism. Menthol has a good safety profile and exerts its anticancer activity via multiple pathways and targets. As a result, it has gained popularity for significantly inhibiting different types of cancer cells by various mechanisms such as induction of apoptosis, cell cycle arrest, disruption of tubulin polymerization, and inhibition of tumor angiogenesis. Owing to the excellent anticancer activity menthol has demonstrated, further research is warranted for developing it as a novel anticancer agent. However, there are limitations and gaps in the current research on menthol, and its antitumor mechanism has not been completely elucidated. It is expected that more basic experimental and clinical studies focusing on menthol and its derivatives will eventually help in its clinical application as a novel anticancer agent.
引用
收藏
页数:13
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