Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease

被引：120

作者：

Zhang, Tianfu ^{[1
,2
]}

Chen, Xiaoyu ^{[3
]}

Yuan, Congmin ^{[1
,2
]}

Pang, Xiaobin ^{[4
,5
]}

Shangguan, Ping ^{[3
]}

Liu, Yisheng ^{[3
,4
,5
]}

Han, Lulu ^{[3
]}

Sun, Jianwei ^{[1
,2
]}

Lam, Jacky W. Y. ^{[1
,2
]}

Liu, Yang

Wang, Jiefei ^{[3
]}

Shi, Bingyang ^{[3
,6
]}

Tang, Ben Zhong ^{[1
,2
,7
]}

机构：

[1] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem, Div Life Sci,Hong Kong Branch,Clear Water Bay,Kowl, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Clear Water Bay, Hong Kong, Peoples R China

[3] Henan Univ, Henan Macquarie Univ, Sch Life Sci, Joint Ctr Biomed Innovat, Kaifeng 475004, Henan, Peoples R China

[4] Henan Univ, Sch Life Sci, Henan Key Lab Brain Targeted Bionanomed, Kaifeng 475004, Peoples R China

[5] Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China

[6] Macquarie Univ, Fac Med & Hlth Sci, Ctr Motor Neuron Dis, Macquarie Med Sch, Sydney, NSW, Australia

[7] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 02期

基金：

中国国家自然科学基金; 澳大利亚国家健康与医学研究理事会;

关键词：

Aggregation-Induced Emission; Alzheimer's Disease; Near-Infrared; Theranostic; beta-Amyloid; AMYLOID-BETA; STRUCTURE PREDICTION; PROTEIN AGGREGATION; FLUORESCENT-PROBES; BRAIN; INHIBITION; PLAQUES; BINDING; AMYLOID-BETA(1-42); VISUALIZATION;

D O I：

10.1002/anie.202211550

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent beta-amyloid (A beta) fibrosis encounter failures due to the blood-brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near-infrared (NIR) aggregation-induced emission (AIE) probe, DNTPH, via balanced hydrophobicity-hydrophilicity strategy. DNTPH binds selectively to A beta fibrils with a high signal-to-noise ratio. In vivo imaging revealed its excellent BBB permeability and long-term tracking ability with high-performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on A beta fibrosis and promotes fibril disassembly, thereby attenuating A beta-induced neurotoxicity. DNTPH treatment significantly reduced A beta plaques and rescued learning deficits in AD mice. Thus, DNTPH serves as the first AIE in vivo theranostic agent for real-time NIR imaging of A beta plaques and AD therapy simultaneously.

引用

页数：10

共 72 条

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