Gelatin/Polyacrylamide-Based Antimicrobial and Self-Healing Hydrogel Film for Wound Healing Application

被引：15

作者：

Bhardwaj, Dimpy ^{[1
,2
]}

Bhaskar, Rakesh ^{[3
]}

Sharma, Amit Kumar ^{[4
,5
]}

Garg, Megha ^{[1
,2
]}

Han, Sung Soo ^{[3
]}

Agrawal, Garima ^{[1
,2
]}

机构：

[1] Indian Inst Technol Mandi, Sch Chem Sci, Mandi 175075, Himachal Prades, India

[2] Indian Inst Technol Mandi, Adv Mat Res Ctr, Mandi 175075, Himachal Prades, India

[3] Yeungnam Univ, Sch Chem Engn, Gyeongbuk 38541, South Korea

[4] Chandigarh Univ, Univ Inst Sci, Dept Chem, Mohali 140413, Punjab, India

[5] Chandigarh Univ, Univ Ctr Res & Dev, Mohali 140413, Punjab, India

来源：

ACS APPLIED BIO MATERIALS | 2024年 / 7卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

self-healing; antimicrobial; woundhealing; silver nanoclusters; drug release; GUM SALAI-GUGGAL; SILVER NANOCLUSTERS; ANTIBACTERIAL ACTIVITY; NANOCOMPOSITE;

D O I：

10.1021/acsabm.3c00903

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, a self-healing, adhesive, and superabsorbent film made of gelatin, poly-(acrylamide), and boric acid (GelAA) was successfully synthesized using a free radical reaction mechanism. The optimized film showed a remarkable 2865 +/- 42% water absorptivity and also exhibited excellent self-healing behavior. The GelAA films were further loaded with silver nanoclusters (AgNCs) and ursodeoxycholic acid (UDC) (loading efficiency = 10%) to develop UDC/Ag/GelAA films. The loading of AgNCs in UDC/Ag/GelAA films helped in exhibiting 99.99 +/- 0.01% antibacterial activity against both Gram-positive and Gram-negative bacteria, making them very effective against bacterial infections. Additionally, UDC/Ag/GelAA films had 77.19 +/- 0.52% porosity and showed 90% of UDC release in 30 h, which helps in improving the cell proliferation. Our research provides an easy but highly effective process for synthesizing a hydrogel film, which is an intriguing choice for wound healing applications without the use of antibiotics.

引用

页码：879 / 891

页数：13

共 62 条

[1]

Agarwal T, 2021, Biomedical Engineering Advances, V2, P100015, DOI [10.1016/j.bea.2021.100015, 10.1016/j.bea.2021.100015, DOI 10.1016/J.BEA.2021.100015]

[2] Dual Responsive Poly(N-vinylcaprolactam) Based Degradable Microgels for Drug Delivery [J].