Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer

被引：15

作者：

Said, Sawsan Sudqi ^{[1
]}

Ibrahim, Wisam Nabeel ^{[1
]}

机构：

[1] Qatar Univ, QU Hlth, Coll Hlth Sci, Dept Biomed Sci, POB 2713, Doha, Qatar

来源：

BIOMEDICINES | 2024年 / 12卷 / 02期

关键词：

resistance; triple-negative breast cancer; PD-1/PD-L1/CTLA-4; TME; MOLECULAR CLASSIFICATION; MESENCHYMAL TRANSITION; RELEVANCE; HALLMARKS; CELLS;

D O I：

10.3390/biomedicines12020369

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC's heterogeneity poses challenges to immunological treatments, inducing resistance mechanisms in the tumor microenvironment. Therapeutic modalities, including immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4, are explored in preclinical and clinical trials. Promising results emerge from combining ICIs with anti-TGF-beta and VISTA, hindering TNBC tumor growth. TNBC cells employ complex evasion strategies involving interactions with stromal and immune cells, suppressing immune recognition through various cytokines, chemokines, and metabolites. The recent focus on unraveling humoral and cellular components aims to disrupt cancer crosstalk within the tumor microenvironment. This review identifies TNBC's latest resistance mechanisms, exploring potential targets for clinical trials to overcome immune checkpoint resistance and enhance patient survival rates.

引用

页数：16

共 74 条

[1] PD-1 Independent Role of PD-L1 in Triple-Negative Breast Cancer Progression [J].

Alkaabi, Duaa ;

Arafat, Kholoud ;

Sulaiman, Shahrazad ;

Al-Azawi, Aya Mudhafar ;

Attoub, Samir .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (07)

[2] Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer [J].

Bardia, A. ;

Hurvitz, S. A. ;

Tolaney, S. M. ;

Loirat, D. ;

Punie, K. ;

Oliveira, M. ;

Brufsky, A. ;

Sardesai, S. D. ;

Kalinsky, K. ;

Zelnak, A. B. ;

Weaver, R. ;

Traina, T. ;

Dalenc, F. ;

Aftimos, P. ;

Lynce, F. ;

Diab, S. ;

Cortes, J. ;

O'Shaughnessy, J. ;

Dieras, V ;

Ferrario, C. ;

Schmid, P. ;

Carey, L. A. ;

Gianni, L. ;

Piccart, M. J. ;

Loibl, S. ;

Goldenberg, D. M. ;

Hong, Q. ;

Olivo, M. S. ;

Itri, L. M. ;

Rugo, H. S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (16) :1529-1541

[3] Tumor Mutational Burden in Breast Cancer: Current Evidence, Challenges, and Opportunities [J].

Barroso-Sousa, Romualdo ;

Pacifico, Jana Priscila ;

Sammons, Sarah ;

Tolaney, Sara M. .

CANCERS, 2023, 15 (15)

[4] Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer [J].

Bense, Rico D. ;

Sotiriou, Christos ;

Piccart-Gebhart, Martine J. ;

Haanen, John B. A. G. ;

van Vugt, Marcel A. T. M. ;

de Vries, Elisabeth G. E. ;

Schroeder, Carolien P. ;

Fehrmann, Rudolf S. N. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2017, 109 (01)

[5] Pirfenidone inhibits stromal collagen deposition and improves intra-tumoral delivery and antitumor efficacy of Pegylated liposomal doxorubicin [J].

Cai, Tiantian ;

Jiang, Jiali ;

Yao, Wendong ;

Hu, Yan ;

Kong, Sisi ;

Fan, Qiaomei ;

Yan, Xingxing ;

Li, Fanzhu ;

Shi, Zheng .

BIOMEDICINE & PHARMACOTHERAPY, 2023, 157

[6] Role of hypoxia-inducible factor-1? and survivin in breast cancer recurrence and prognosis [J].

Cao, Qian ;

Mushajiang, Munire ;

Tang, Cheng-qiong ;

Ai, Xiu-qing .

HELIYON, 2023, 9 (03)

[7] Role of Tumor-Associated Myeloid Cells in Breast Cancer [J].

Cha, Yoon Jin ;

Koo, Ja Seung .

CELLS, 2020, 9 (08) :1-27

[8] TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure [J].

Chakravarthy, Ankur ;

Khan, Lubaba ;

Bensler, Nathan Peter ;

Bose, Pinaki ;

De Carvalho, Daniel D. .

NATURE COMMUNICATIONS, 2018, 9

[9] Interleukin-10: A double-edged sword in breast cancer [J].

Chang, Chun-Ming ;

Lam, Ho Yin Pekkle ;

Hsu, Hao-Jen ;

Jiang, Shinn-Jong .

TZU CHI MEDICAL JOURNAL, 2021, 33 (03) :203-211

[10] DIETARY PATTERNS ASSOCIATED WITH INCREASED ABUNDANCE OF AKKERMANSIA MUCINIPHILA POTENTIATES ANTI-PD-L1 IMMUNE CHECKPOINT BLOCKADE RESPONSE IN TRIPLE-NEGATIVE BREAST CANCER [J].

Clear, Kenysha ;

Stirling, Elizabeth ;

Wilson, Adam ;

Soto-Pantoja, David ;

Cook, Katherine .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 :A1354-A1354

← 1 2 3 4 5 6 7 8 →