Synthesis of β-Nitroamines and α-Aminonitriles by I2-Mediated Oxidative C-C Bond Formation

被引：2

作者：

Li, Qianmin ^{[1
,2
]}

Wang, Manman ^{[1
]}

Yu, Wenquan ^{[1
]}

Chang, Junbiao ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Sch Chem Engn, Zhengzhou 450001, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 11期

基金：

中国国家自然科学基金;

关键词：

iodine; C-C bond formation; tertiary amine; beta-nitroamine; alpha-aminonitrile; DEHYDROGENATIVE COUPLING REACTION; ARYL-SUBSTITUTED AZACYCLES; SOLVENT-FREE SYNTHESIS; ONE-POT SYNTHESIS; H FUNCTIONALIZATION; TERTIARY-AMINES; PHOTOREDOX CATALYSIS; MOLECULAR-OXYGEN; CYANATION; IODINE;

D O I：

10.6023/cjoc202305021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free C-C bond formation reaction is developed employing molecular iodine as the sole oxidant to access beta-nitroamines, alpha-aminonitriles and alpha-aminophosphonates from readily accessible tertiary amines with nitroalkanes, trimethylsilyl cyanide and phosphite, respectively. The present synthetic approach is operationally simple, has a broad substrate scope, and can be successfully conducted on a gram scale.

引用

页码：3966 / 3976

页数：11

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