The effect of paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component on heart rate and heart rate variability in healthy subjects

被引:2
|
作者
Haakana, P. [1 ,2 ,3 ]
Holopainen, K. [1 ,2 ]
Natkynmaki, A. [1 ,2 ]
Kirveskari, E. [1 ,2 ,4 ,5 ]
Tarvainen, M. P. [4 ,6 ,7 ]
Shulga, A. [1 ,2 ,4 ,8 ]
机构
[1] Univ Helsinki, Helsinki Univ Hosp, HUS Diagnost Ctr, BioMag Lab, Helsinki, Finland
[2] Aalto Univ, Sch Sci, Helsinki, Finland
[3] Helsinki Univ Hosp, New Childrens Hosp, Mot Anal Lab, Helsinki, Finland
[4] Univ Helsinki, Helsinki, Finland
[5] Helsinki Univ Hosp, HUS Med Imaging Ctr, Clin Neurophysiol, Clin Neurosci, Helsinki, Finland
[6] Univ Eastern Finland, Dept Tech Phys, Kuopio, Finland
[7] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland
[8] Helsinki Univ Hosp, Dept Phys & Rehabil Med, Helsinki, Finland
来源
FRONTIERS IN REHABILITATION SCIENCES | 2023年 / 4卷
基金
芬兰科学院;
关键词
transcranial magnetic stimulation; peripheral nerve stimulation; parasympathetic activity; autonomic nervous system; cardiovascular function; TRANSCRANIAL MAGNETIC STIMULATION; SPINAL-CORD-INJURY; HUMAN MOTOR CORTEX; BRAIN-STIMULATION; PLASTICITY; INHIBITION; INDUCTION; TMS;
D O I
10.3389/fresc.2023.1200958
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
ObjectiveA novel protocol for paired associative stimulation (PAS), called high PAS, consists of high-intensity transcranial magnetic stimulation (TMS) and high-frequency peripheral nerve stimulation (PNS). High PAS was developed for spinal cord injury rehabilitation and targets plastic changes in stimulated pathways in the corticospinal tract, which improves motor function. As therapy interventions can last many weeks, it is important to fully understand the effects of high PAS, including its effect on the cardiovascular system. Heart rate variability (HRV) has been used to measure changes in both sympathetic and parasympathetic systems. MethodsWe used short-term HRV measurements to evaluate the effects of one 20-min session of high PAS on 17 healthy individuals. HRV was recorded for 5 min before (PRE), during (STIM), immediately after (POST), 30 min after (POST30), and 60 min after (POST60) the stimulation. Five participants repeated the HRV setup with sham stimulation. ResultsA significant decrease in low-frequency (LF) power (n.u.) (p = 0.002), low-frequency to high-frequency (HF) ratio (p = 0.017), in Poincare plot [the standard deviation of RR intervals perpendicular to (SD1) and along (SD2) the line of identity SD2/SD1 ratio p < 0.001], and an increase in HF power (n.u.) (p = 0.002) were observed between PRE and STIM conditions; these changes were fully reversible immediately after stimulation. PRE to POST by 3% (p = 0.015) and continued to decline until POST60 by 5% (p = 0.011). LF power (ms(2)) (p = 0.017) and SD2 (p = 0.015) decreased from PRE to STIM and increased from PRE to POST (p = 0.025 and p = 0.017, respectively). The results from sham PAS exhibited a trend similar to active high-PAS stimulation. ConclusionsHigh PAS does not have sustained effects during 60-min follow-up on cardiovascular functions, as measured by HRV. None of the short-term results indicates activation of the sympathetic nervous system in healthy individuals. Observed changes in HRV indicate higher parasympathetic activity during stimulation, which is reversible, and is plausibly explained by the fact that the participants spend 20 min without moving, talking, or using phones while being stimulated.
引用
收藏
页数:10
相关论文
共 50 条
  • [11] DIMENSIONS OF CARDIOCEPTION IN RELATION TO HEART RATE, HIGH-FREQUENCY HEART RATE VARIABILITY, AND TRAIT ANXIETY
    Grant, Shara
    Van Orden, Cassie
    Derosier, Nicole
    Brewer, Nicholas
    Rosazza, Carolyn
    Friedman, Bruce
    PSYCHOPHYSIOLOGY, 2018, 55 : S58 - S58
  • [12] A novel paired associative stimulation protocol with a high-frequency peripheral component: A review on results in spinal cord injury rehabilitation
    Shulga, Anastasia
    Lioumis, Pantelis
    Kirveskari, Erika
    Savolainen, Sarianna
    Makela, Jyrki P.
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2021, 53 (09) : 3242 - 3257
  • [13] Paired Associative Stimulation with High-Frequency Peripheral Component Leads to Enhancement of Corticospinal Transmission at Wide Range of Interstimulus Intervals
    Shulga, Anastasia
    Zubareva, Aleksandra
    Lioumis, Pantelis
    Makela, Jyrki P.
    FRONTIERS IN HUMAN NEUROSCIENCE, 2016, 10
  • [14] Effect of Magnesium on Heart Rate Variability in Healthy Subjects
    Brilla, Lorrie
    Teichler, Liza
    Hahn, Teresa
    Freeman, Jeanne
    Li, Ying
    FASEB JOURNAL, 2010, 24
  • [15] The effect of age on the heart rate variability of healthy subjects
    Garavaglia, Leopoldo
    Gulich, Damian
    Defeo, Magdalena M.
    Mailland, Julieta Thomas
    Irurzun, Isabel M.
    PLOS ONE, 2021, 16 (10):
  • [16] THE HIGH-FREQUENCY COMPONENT OF HEART-RATE-VARIABILITY REFLECTS CARDIAC PARASYMPATHETIC MODULATION RATHER THAN PARASYMPATHETIC TONE
    HEDMAN, AE
    HARTIKAINEN, JEK
    TAHVANAINEN, KUO
    HAKUMAKI, MOK
    ACTA PHYSIOLOGICA SCANDINAVICA, 1995, 155 (03): : 267 - 273
  • [17] THE VALIDITY OF THE HIGH-FREQUENCY SPECTRAL COMPONENT OF HEART-RATE-VARIABILITY AS AN INDEX OF PARASYMPATHETIC NERVOUS ACTIVITY DURING EXERCISE
    YAMAMOTO, M
    SATO, H
    IINUMA, H
    FU, LT
    TAKAHASHI, N
    KATO, K
    CIRCULATION, 1992, 86 (04) : 589 - 589
  • [18] Consciously Controlled Breathing Decreases the High-Frequency Component of Heart Rate Variability by Inhibiting Cardiac Parasympathetic Nerve Activity
    Sasaki, Konosuke
    Maruyama, Ryoko
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 233 (03): : 155 - 163
  • [19] LOW-FREQUENCY COMPONENT OF HEART-RATE-VARIABILITY
    INTRONA, RPS
    MONTANO, N
    YODLOWSKI, EH
    MARTIN, DC
    PRUETT, JK
    CRUMRINE, RS
    ANESTHESIOLOGY, 1995, 83 (04) : 884 - 886
  • [20] Modelling the shift of the low frequency component of heart rate variability
    Raymond, B
    Mazumdar, J
    Nandagopal, D
    COMPUTERS IN CARDIOLOGY 1997, VOL 24, 1997, 24 : 407 - 410