Role of Midkine in Cancer Drug Resistance: Regulators of Its Expression and Its Molecular Targeting

被引：25

作者：

Saikia, Minakshi ^{[1
]}

Cheung, Nathan ^{[1
]}

Singh, Abhay Kumar ^{[1
]}

Kapoor, Vaishali ^{[1
,2
]}

机构：

[1] Washington Univ St Louis, Sch Med, Dept Radiat Oncol, St Louis, MO 63108 USA

[2] Siteman Canc Ctr, St Louis, MO 63108 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 10期

关键词：

midkine; drug resistance; cancer targeting; transcriptional regulators; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; GROWTH-FACTOR; TUMOR-GROWTH; ANTISENSE OLIGONUCLEOTIDES; DIFFERENTIAL EXPRESSION; SPECIFICITY PROTEIN-1; DOWN-REGULATION; GLIOMA-CELLS; IN-VITRO;

D O I：

10.3390/ijms24108739

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers and indicates its association with multi-drug resistance in cancer. MDK, a secretory cytokine found in blood, can be exploited as a potent biomarker for the non-invasive detection of drug resistance expressed in various cancers and, thereby, can be targeted. We summarize the current information on the involvement of MDK in drug resistance, and transcriptional regulators of its expression and highlight its potential as a cancer therapeutic target.

引用

页数：14

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