CRISPR/Cas9 genome editing approaches for psychiatric research

被引：3

作者：

Gutierrez-Rodriguez, Araceli ^{[1
,2
]}

Cruz-Fuentes, Carlos S. ^{[3
]}

Genis-Mendoza, Alma D. ^{[1
,4
]}

Nicolini, Humberto ^{[1
]}

机构：

[1] Inst Nacl Med Genom, Lab Genom Enfermedades Psiquiatr & Neurodegenerat, Mexico City, Mexico

[2] Univ Nacl Autonoma Mexico, Programa Posgrad Ciencias Biol, Mexico City, Mexico

[3] Inst Nacl Psiquiatria Ramon De La Fuente Muniz, Dept Genet Psiquiatr, Subdirecc Invest Clin, Mexico City, Mexico

[4] Hosp Psiquiatr Infantil Juan N Navarro, Serv Atenc Psiquiatr, Secretaria Salud, Mexico City, Mexico

来源：

BRAZILIAN JOURNAL OF PSYCHIATRY | 2023年 / 45卷 / 02期

关键词：

Autism spectrum disorder; CRISPR-Cas; gene editing; psychiatry; schizophrenia; SCHIZOPHRENIA; DISEASE; CRISPR-CAS9; INDIVIDUALS; GENERATION; VARIANTS; GENETICS; INSIGHTS; THERAPY; CELLS;

D O I：

10.47626/1516-4446-2022-2913

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Currently, genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), are predominantly used to model genetic diseases. This genome editing system can correct point or frameshift mutations in risk genes. Here, we analyze and discuss the advantages of genome editing, its current applications, and the feasibility of the CRISPR/Cas9 system in research on psychiatric disorders. These disorders produce cognitive and behavioral alterations and their etiology is associated with polygenetic and environmental factors. CRISPR/Cas9 may reveal the biological mechanisms of psychiatric disorders at a basic research level, translating a suitable clinical approach for use in the diagnosis and treatment of psychiatric disorders. Genetic diagnosis and treatment for these disorders have not yet been fully established in psychiatry due to the limited understanding of their heterogeneity and polygenicity. We discuss the challenges and ethical issues in using CRISPR/Cas9 as a tool for diagnosis or gene therapy.

引用

页码：137 / 145

页数：9

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