Neuroprotective effects of carnosine in a mice stroke model concerning oxidative stress and inflammatory response

被引：6

作者：

Hu, Xinran ^{[1
]}

Fukui, Yusuke ^{[1
]}

Feng, Tian ^{[1
]}

Bian, Zhihong ^{[1
]}

Yu, Haibo ^{[1
]}

Morihara, Ryuta ^{[1
]}

Hu, Xiao ^{[1
]}

Bian, Yuting ^{[1
]}

Sun, Hongming ^{[1
]}

Takemoto, Mami ^{[1
]}

Nakano, Yumiko ^{[1
]}

Yunoki, Taijun ^{[1
]}

Abe, Koji ^{[1
]}

Yamashita, Toru ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, 2-5-1 Shikata Cho,Kita Ku, Okayama 7008558, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2023年 / 447卷

关键词：

Ischemic stroke; Carnosine; Middle cerebral artery occlusion; Oxidative stress; Inflammation; Pyroptosis; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE; EXPRESSION; ACTIVATION; MECHANISMS; OXYGENASE; PROTECTS; MOUSE;

D O I：

10.1016/j.jns.2023.120608

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Carnosine (beta-alanyl-L-histidine) is a natural dipeptide with multiple neuroprotective properties. Previous studies have advertised that carnosine scavenges free radicals and displays anti-inflammatory activity. However, the underlying mechanism and the efficacies of its pleiotropic effect on prevention remained obscure. In this study, we aimed to investigate the anti-oxidative, anti-inflammative, and anti-pyroptotic effects of carnosine in the transient middle cerebral artery occlusion (tMCAO) mouse model. After a daily pre-treatment of saline or carnosine (1000 mg / kg / day) for 14 days, mice (n = 24) were subjected to tMCAO for 60 min and continuously treated with saline or carnosine for additional 1 and 5 days after reperfusion. The administration of carnosine significantly decreased infarct volume 5 days after the tMCAO (*p < 0.05) and effectively suppressed the expression of 4-HNE, 8-OHdG, Nitrotyrosine 5 days, and RAGE 5 days after tMCAO. Moreover, the expression of IL-1 beta was also significantly suppressed 5 days after tMCAO. Our present findings demonstrated that carnosine effectively relieves oxidative stress caused by ischemic stroke and significantly attenuates neuroinflammatory responses related to IL-1 beta, suggesting that carnosine can be a promising therapeutic strategy for ischemic stroke.

引用

页数：9

共 38 条

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