Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization

被引：2

作者：

Xu, Xiao-Bo ^{[1
,2
]}

Hao, Li-Qiang ^{[1
,2
]}

Liu, Xian ^{[1
,2
]}

Wang, Yang-Yang ^{[1
,2
]}

Yang, Zhao-Zi-Yuan ^{[1
,2
]}

Yu, Xiao ^{[1
,2
]}

Ding, Dong ^{[3
]}

Ji, Ya-Fei ^{[1
,2
]}

机构：

[1] Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] Chongqing Bosen Pharmaceut Co Ltd, Fuan Pharmaceut Grp, Huanan Yi Rd, Chongqing 401254, Peoples R China

来源：

SYNLETT | 2024年 / 35卷 / 19期

基金：

中国国家自然科学基金;

关键词：

N -substituted pyrrole-2-carboxaldehydes; atom-economic reactions; N -substituted maleimides; C-H activation; tricyclic pyrrolizines; ONE-POT SYNTHESIS; FLUORINE SCAN; C-F; CYCLOADDITION CASCADES; THROMBIN INHIBITORS; 3-COMPONENT; INDOLIZIDINES; PK(A);

D O I：

10.1055/a-2290-1682

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an atom-economic method for the synthesis of fused-ring pyrrolizine derivatives by a cycloaddition reaction of easily accessible N-substituted pyrrole-2-carboxaldehydes with N-substituted maleimides in the presence of di-tert-butyl peroxide has been successfully developed. A total of 23 compounds were obtained by using this method, with a maximum yield of 72%, providing a practical and efficient method for the synthesis of tricyclic pyrrolizine frameworks.

引用

收藏

页码：2236 / 2240

页数：5

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